Meta AnalysisID 3673
硝苯地平对比阿托西班治疗先兆早产：一项个体参与者数据Meta分析
CRD42016024244
We plan to perform an Individual Participant Data Meta-Analysis (IPDMA) of randomized clinical trials to provide clinicians with the best available evidence on the effectiveness and neonatal outcome of tocolysis using ei
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3673
- Evidence Id
- 12231
- Core Evidence Id
- 12231
- Source Meta Analysis Id
- 3632
- Herb2 Meta Analysis Id
- HBMA003632
- Crd Id
- CRD42016024244
- Title
- Nifedipine versus atosiban in treatment of threatened preterm labor: an individual participant data meta-analysis
- Review Question
- We plan to perform an Individual Participant Data Meta-Analysis (IPDMA) of randomized clinical trials to provide clinicians with the best available evidence on the effectiveness and neonatal outcome of tocolysis using either nifedipine or atosiban.
- Study Type Included
- RCTs
- Condition Being Studied
- Tocolytics are administered in threatened preterm birth to delay birth for at least 48 hours to let antenatal corticosteroids do their work. Nifedipine and atosiban are both commonly used tocolytic drugs.
- Participant
- Pregnant women, between 24-34 weeks of gestational age with signs of threatened preterm birth (ruptured membranes and contractions, cervical length shortening, fetal fibronectin test results). Exclusion criteria: signs of fetal stress, congenital malformations, contraindications for tocolytic drugs.
- Animal
- Human Disease Modelled
- Intervention
- 48 hours of tocolytic treatment with either: - nifedipine orally, or - atosiban intravenous
- Comparator Control
- see above.
- Main Outcome
- The primary outcome will be a composite of neonatal morbidities and perinatal mortality. Neonatal morbidities include bronchopulmonary dysplasia (BPD), periventricular leucomalacia (PVL), intraventricular haemorrhage, necrotising enterocolitis (NEC) and culture proven sepsis.
- Outcome Measure
- Additional Outcome
- Secondary outcomes are time to delivery, gestational age at delivery and days on ventilation support, successful 48 hours of tocolysis, maternal side effects and blood loss during delivery.
- Study Method
- Individual patient data (IPD) meta-analysis, Intervention
- Keyword
- Female; Humans; Infant, Newborn; Nifedipine; Obstetric Labor, Premature; Pregnancy; Vasotocin
- Contact
- Mr van Winden [email protected]
- Organisational Affiliation
- Amsterdam UMC, Department Obstetrics and Gynecology
- Funding Source
- No funding.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- a short systematic review and meta-analysis will be published alongside the primary paper of our nifedipine vs. atosiban trial (soon to be published in The Lancet).
- Published Protocol
- Review Type
- Language
- English
- Country
- Iran, Iraq, Israel, Netherlands
- Review Stage
- Review Ongoing
- First Submission Date
- 2018-07-26
- Registration Date
- 2016-02-25
- Anticipated Start Date
- 2015-06-01
- Anticipated Completion Date
- 2018-12-01
- Title Cn
- 硝苯地平对比阿托西班治疗先兆早产：一项个体参与者数据Meta分析
- Title En
- Nifedipine versus atosiban in treatment of threatened preterm labor: an individual participant data meta-analysis
- Bilingual Status
- complete