Meta AnalysisID 3607
哌替啶对比曲马多预防术后寒战：随机对照试验的系统评价
CRD42021260557
This systematic review and meta-analysis will compare the efficacy and safety of intravenous use of meperidine with tramadol for the prevention of postoperative shivering.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3607
- Evidence Id
- 12165
- Core Evidence Id
- 12165
- Source Meta Analysis Id
- 3565
- Herb2 Meta Analysis Id
- HBMA003565
- Crd Id
- CRD42021260557
- Title
- Meperidine versus tramadol for the prevention of postoperative shivering: a systematic review of randomized controlled trials
- Review Question
- This systematic review and meta-analysis will compare the efficacy and safety of intravenous use of meperidine with tramadol for the prevention of postoperative shivering.
- Study Type Included
- Inclusion criteria: randomized controlled trials will be included in this review. Exclusion criteria: cross-over studies; pesudo-randomized controlled trials.
- Condition Being Studied
- Postoperative shivering is a symptom involving involuntary muscles movement. Postoperative shivering frequently occurs after surgery under either general or regional anesthesia. Previous meta-analysis reported that its incidence was reported up to 53-55%. Postoperative shivering is not only subjectively uncomfortable but is also physiologically stressful and harmful.
- Participant
- Inclusion criteria: patients who underwent surgery under either general or regional anesthesia. Exclusion criteria: nonhuman trials, studies in healthy volunteers
- Animal
- Human Disease Modelled
- Intervention
- Inclusion Criteria: studies with intraoperative use of meperidine will be included in this systematic review with no restraints on timing and dosage of administration Exclusion Criteria: oral or intrathecal use of meperidine
- Comparator Control
- Inclusion Criteria: studies with intraoperative use of tramadol will be included in this systematic review with no restraints on timing and dosage of administration Exclusion Criteria: oral or intrathecal use of tramadol
- Main Outcome
- incidence of shivering; The grade of shivering scored more than 2 was identified as shivering. The shivering was graded using a five-point scale: grade 0, patients without shivering; grade 1, patients with piloerection, peripheral vasoconstriction, peripheral cyanosis without other specific cause, but without visible muscular contractions; grade 2, contraction observed limited to a bunch of muscle contraction; grade 3, contraction observed in more than one group of muscles; grade 4, the whole body clear muscular activity. Measures of effect The incidence of postoperative shivering is dichotomous variable. Thus, relative risk with relevant 95% confidence intervals will be calculated.
- Outcome Measure
- Additional Outcome
- Postoperative nausea or vomiting; Tracheal extubation time Measures of effect Postoperative nausea or vomiting is binary outcome, relative risk with pertinent 95% confidence interval will be calculated. Tracheal extubation time is continuous variable, weighted mean difference or standardized mean differnce with 95% confidence interval will be calculated.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Analgesics, Opioid; Humans; Meperidine; Randomized Controlled Trials as Topic; Shivering; Tramadol
- Contact
- Meng Lv [email protected]
- Organisational Affiliation
- The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital
- Funding Source
- Natural Science Funndation of Shandong Province Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> ZR2016HL02
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-09-25
- Registration Date
- 2021-10-25
- Anticipated Start Date
- 2021-10-01
- Anticipated Completion Date
- 2022-04-30
- Title Cn
- 哌替啶对比曲马多预防术后寒战：随机对照试验的系统评价
- Title En
- Meperidine versus tramadol for the prevention of postoperative shivering: a systematic review of randomized controlled trials
- Bilingual Status
- complete