Meta AnalysisID 3597
多磺酸粘多糖乳膏治疗非渗出性湿疹的疗效和安全性
CRD42021265735
This study aims to evaluate the efficacy and safety of mucopolysaccharide polysulfate cream for the treatment of nonexudative eczema.
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Record Fields
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- Meta Analysis Id
- 3597
- Evidence Id
- 12155
- Core Evidence Id
- 12155
- Source Meta Analysis Id
- 3554
- Herb2 Meta Analysis Id
- HBMA003554
- Crd Id
- CRD42021265735
- Title
- The efficacy and safety of mucopolysaccharide polysulfate cream for the treatment of nonexudative eczema
- Review Question
- This study aims to evaluate the efficacy and safety of mucopolysaccharide polysulfate cream for the treatment of nonexudative eczema.
- Study Type Included
- Only the randomized controlled trials (RCTs) on mucopolysaccharide polysulfate cream for the treatment of nonexudative eczema were included in this review. RCTs published in the form of dissertations were also included.
- Condition Being Studied
- Eczema, as a common skin disease, is characterized by a complex etiology and apparent pruritus. The clinical manifestation of eczema is diverse, and eczema lesions can develop in the whole body and are usually symmetric. Pruritus is one of the most typical symptoms of the disease. The burdens of eczema for patients, their family and friends, the healthcare system and society are substantial. For the treatment of eczema, moisturizers can be the main primary treatment for mild disease and should be part of the regimen for moderate and severe disease, such as glycerol, lactic acida and urea. Mucopolysaccharide polysulfate cream are widely used as moisturizers for dry skin. A lot of articles have shown that it alone or combined with anti-inflammatory agents, such as topical corticosteroids (TCS) and topical calcineurin inhibitors (TCI), can treat eczema effectively.
- Participant
- Patients diagnosed with nonexudative eczema, regardless of age and gender.
- Animal
- Human Disease Modelled
- Intervention
- The experimental group were treated with mucopolysaccharide polysulfate cream alone, or mucopolysaccharide polysulfate cream combined with topical anti-inflammatory agents, including TCS and TCI.
- Comparator Control
- The control groups were treated with placebo, other moisturizers, such as urea cream and vaseline ointment, or topical anti-inflammatory agents, including TCS and TCI.
- Main Outcome
- Total effectiveness rate and total symptom score
- Outcome Measure
- Additional Outcome
- VAS score for pruritus, recurrence rate, tests for skin barrier fucation, including epidermal water loss, cuticular water content, and epidermal sebum content, laboratory tests, including IL-4 and IFN-γ, and adverse events
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Eczema; Glycosaminoglycans; Humans; Ointments; mucopolysaccharide polysulfate
- Contact
- Ming Li [email protected]
- Organisational Affiliation
- Beijing Friendship Hospital, Capital Medical University,
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-07-03
- Registration Date
- 2021-08-04
- Anticipated Start Date
- 2021-08-01
- Anticipated Completion Date
- 2021-10-31
- Title Cn
- 多磺酸粘多糖乳膏治疗非渗出性湿疹的疗效和安全性
- Title En
- The efficacy and safety of mucopolysaccharide polysulfate cream for the treatment of nonexudative eczema
- Bilingual Status
- complete