Meta AnalysisID 3593
高渗盐水和甘露醇用于脑卒中后颅内压增高患者：一项系统评价和Meta分析
CRD42021275904
To evaluate the efficacy and safety of HTS solutions and mannitol in patients with elevated ICP secondary to stroke by examining the data from randomized controlled trials
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Record Fields
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- Meta Analysis Id
- 3593
- Evidence Id
- 12151
- Core Evidence Id
- 12151
- Source Meta Analysis Id
- 3550
- Herb2 Meta Analysis Id
- HBMA003550
- Crd Id
- CRD42021275904
- Title
- Hypertonic saline and mannitol in patients with Increased Intracranial Pressure after Stroke：A systematic Review and meta-analysis
- Review Question
- To evaluate the efficacy and safety of HTS solutions and mannitol in patients with elevated ICP secondary to stroke by examining the data from randomized controlled trials
- Study Type Included
- RCT are eligible for inclusion, case report, comments, cohort studies, animal studies are excluded.
- Condition Being Studied
- Increased ICP after stroke, including ischemic stroke as well as intracerebral hemmorage(ICH), leads to particularly high rate of neurological deterioration and mortality. Mannitol and hypertonic saline(HS) are both commonly used infusion as osmotherapy treatment in an effort to reduce the ICP. At present, the safety, effectiveness and scope of application of mannitol versus HS deserve further study.
- Participant
- Eligibility criteria for study inclusion consisted of full text available prospective, randomized clinical trials that compared HS and mannitol solutions administered intravenously in adult humans with evidence (clinical or measured) of elevated ICP secondary to stroke.Cross-over studies were eligible for inclusion, provided the initial treatment was randomized. The following exclusion criteria were applied: subarachnoid hemorrhage, case report, comments, cohort studies, animal studies, reviews and studies that included only pediatric patients (<16 years old).
- Animal
- Human Disease Modelled
- Intervention
- The intervention were hypertonic saline and mannitol.
- Comparator Control
- The intervention were hypertonic saline and mannitol.
- Main Outcome
- intracranial pressure (ICP) Measures of effect Additional outcomes were assessed using the mean differences(MD) or standardized mean difference (SMD) with the 95% CI.
- Outcome Measure
- Additional Outcome
- 1.cerebral perfusion pressure(CPP), 2.mean arterial pressure(MAP), 3.serum sodium level 4. plasma osmolality Measures of effect Additional outcomes were assessed using the mean differences(MD) or standardized mean difference (SMD) with the 95% CI.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Diuretics, Osmotic; Humans; Intracranial Pressure; Mannitol; Saline Solution, Hypertonic; Stroke
- Contact
- Ruihong Wang [email protected]
- Organisational Affiliation
- Guangzhou University of Chinese Medicine
- Funding Source
- Neurological Intensive Care Unit, Guangdong provincial hospital of TCM, Guangzhou University of Chinese Medicine,
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-08-29
- Registration Date
- 2021-09-29
- Anticipated Start Date
- 2021-08-21
- Anticipated Completion Date
- 2021-10-10
- Title Cn
- 高渗盐水和甘露醇用于脑卒中后颅内压增高患者：一项系统评价和Meta分析
- Title En
- Hypertonic saline and mannitol in patients with Increased Intracranial Pressure after Stroke：A systematic Review and meta-analysis
- Bilingual Status
- complete