Meta AnalysisID 357
胡萝卜摄入与癌症风险关联的系统评价和Meta分析
CRD42019124009
If carrot consumption is associated with reduced risk of cancer. If the effects of carrot consumption on cancer risks is dose dependent. The review will primarily address effects on cancer risk of carrot intake, but will
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 357
- Evidence Id
- 8915
- Core Evidence Id
- 8915
- Source Meta Analysis Id
- 336
- Herb2 Meta Analysis Id
- HBMA000336
- Crd Id
- CRD42019124009
- Title
- A systematic review and meta-analysis of associations between carrot consumption and cancer risks
- Review Question
- If carrot consumption is associated with reduced risk of cancer. If the effects of carrot consumption on cancer risks is dose dependent. The review will primarily address effects on cancer risk of carrot intake, but will also assess if this effect is over and above that offered by consumption of vegetables in general.
- Study Type Included
- We will include all relevant study designs; case control studies, cohort studies and randomised controlled trials, addressing a relationship between direct or indirect measures of consumption of carrots and cancer; providing incidence or mortality rates, as odds ratio (ORs) or relative risk (RR) with 95% confidence intervals (CI) or equivalent. Studies addressing only the intake of carotenoid supplements will not be included in the study. In vitro studies and animal trials will not be included.
- Condition Being Studied
- It is generally well known that a higher consumption of some fruits and vegetables results in a lower risk of cancer. Carrot is one very important vegetable that has been claimed to possess effects against various cancers in both animal and In vitro studies, which may be related to its particular contents of phytochemicals. However, most previous epidemiological studies were focused on general nutrients rather than specific foods, so despite multiple studies collecting pertinent data, the association between carrot intake and cancer incidence among studied populations has not been specifically addressed. Small meta-analyses (5-10 studies included in each) have been conducted on associations between dietary carrot intake and a few specific cancers: prostate (Xu et al., 2014), gastric (Fallazadeh et al., 2015) and breast cancer (Chen et al., 2018) cancer, all showing negative correlations between intake and cancer risk, but no systematic reviews have addressed cancer risk in general nor included and compared direct and indirect intake assessments. To address this gap in this area of research, the systematic review and meta-analysis of eligible studies is set out to investigate the evidence on the relationship between carrot consumption and reduction of cancer incidence.
- Participant
- Inclusion criteria: Participants will include all ages irrespective of gender. All articles in English, Spanish and French; other languages will be considered depending on the availability of relevant interpreters. Exclusion criteria: In vitro studies and animal trials.
- Animal
- Human Disease Modelled
- Intervention
- All studies that include assessment of dietary consumption of carrots and its association with cancer. Assessments of dietary consumption can be direct or indirect estimates of amount of carrot intakes; direct estimates are defined as studies involving actual carrot intake assessed from food diaries or food frequency questionnaires or as a controlled intervention. Indirect estimates are as measure of dietary alpha-carotene as marker of carrot intake, either as concentrations in plasma, or as intakes derived from dietary assessments where the actual carrot intake data are not available. Studies which involve dietary carotenoids (example beta-carotene) primarily as supplements will not be included. Outcomes included are cancer risk/incidence, cancer mortality.
- Comparator Control
- We will compare the differences of standardised mean of the outcome variables in the groups with high and minimal consumption of carrots-based diets within the study.
- Main Outcome
- The main outcome of this study is a measure of difference in risk of diagnosis of any cancer between the groups with highest and lowest directly or indirectly measured carrot intake. Measures of effect
- Outcome Measure
- Additional Outcome
- Effects of directly or indirectly measured carrot intake on survival time after cancer diagnosis, as trends across all intake doses. Difference in risk of cancer mortality between the groups with highest and lowest directly or indirectly measured carrots intake. Dose-dependent differences in risk of cancer mortality or of cancer diagnosis, as trends across all intake doses. Measures of effect
- Study Method
- Diagnostic, Epidemiologic, Intervention, Meta-analysis, Methodology, Narrative synthesis, Pre-clinical, Prevention, Prognostic, Prospective meta-analysis (PMA), Synthesis of qualitative studies, Systematic review
- Keyword
- Daucus carota; Humans; Neoplasms; Physiological Phenomena; Risk
- Contact
- Charles Chijioke Ojobor [email protected]
- Organisational Affiliation
- Newcastle University http://www.ncl.ac.uk
- Funding Source
- Tertiary Education Trust Fund (TETFund), Nigeria/Newcastle University, United Kingdom.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- England
- Review Stage
- Review Ongoing
- First Submission Date
- 2019-02-01
- Registration Date
- 2019-02-14
- Anticipated Start Date
- 2019-02-08
- Anticipated Completion Date
- 2019-04-30
- Title Cn
- 胡萝卜摄入与癌症风险关联的系统评价和Meta分析
- Title En
- A systematic review and meta-analysis of associations between carrot consumption and cancer risks
- Bilingual Status
- complete