Meta AnalysisID 3550
Morina的愈合潜力及其体内药理特性：系统评价
CRD42021230363
Which parameters associated with the healing process are reduced by morina in in vivo models that involve the inflammatory, antioxidant, angiogenic, fibrotic and antibacterial process compared to control animals? Context
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Record Fields
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- Meta Analysis Id
- 3550
- Evidence Id
- 12108
- Core Evidence Id
- 12108
- Source Meta Analysis Id
- 3506
- Herb2 Meta Analysis Id
- HBMA003506
- Crd Id
- CRD42021230363
- Title
- HEALING POTENTIAL OF MORINA AND ITS PHARMACOLOGICAL PROPERTIES IN VIVO: A SYSTEMATIC REVIEW
- Review Question
- Which parameters associated with the healing process are reduced by morina in in vivo models that involve the inflammatory, antioxidant, angiogenic, fibrotic and antibacterial process compared to control animals? Context and rationale The skin is the largest organ in the human body (WONG et al., 2016) and its structure has the function of protecting internal tissues against mechanical damage, microbial infection, ultraviolet radiation and extreme temperature (SORG, 2017). A wound is generated when loss of skin integrity occurs, several metabolic pathologies such as diabetes, genetic diseases, such as sickle cell disease and age are predisposed to changes in the healing process, leading to long-term sequelae (MONACO; LAWRENCE, 2003; BROUGHTON; JANIS; ATTINGER, 2006; SORG, 2017). These have a significant impact on patients and the health economy (OLSSON et al., 2019). In the United States, wounds that do not heal are responsible for more than $ 50 billion spent on health, surgical and traumatic incisions for nearly $ 12 billion, and burns for $ 7.5 billion of health spending each year (SEN et al., 2009; FIFE; CARTER, 2012; RODRIGUES et al. 2019). Although there are several therapies for the treatment of wounds, they are only moderately effective, requiring the search for new therapies for the healing process (SEN et al., 2009; SORG et al., 2017). Pre-clinical studies with laboratory animals provide strong scientific evidence and have long aided in the discovery of new therapies for various diseases (WEI; PU; ZHAO, 2017). This work is intended to conduct a systematic review about the use of morin in preclinical studies in vivo that can elucidate the mechanism of action and how it can assist in the wound healing process.
- Study Type Included
- Inclusion criteria: Study in in vivo experiments on anti-inflammatory, antioxidant, healing, angiogenic, fibrotic and antibacterial activity Exclusion criteria: Pharmacological activities unrelated to healing activity, Studies without control group.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: To be included in this systematic review, studies must be performed on animal models regardless of the sex and species of the animal. The disease model evaluated should be any inflammatory, antioxidant, wound healing, angiogenic or fibrotic process. Exclusion criteria: Studies performed in silico or ex vivo models should be excluded from this systematic review. In addition, studies in human being or genetic evaluation studies also should not be included in this research.
- Human Disease Modelled
- Wound Healing
- Intervention
- Inclusion criteria: Morin treatment, regardless of dose, route of administration and time of use of morina Exclusion criteria: Treatment with morin associated with other substances in vivo or in vitro experiments.
- Comparator Control
- Inclusion criteria: Control animals treated with vehicle or standard medication based on the model in the studies. Exclusion criteria: Studies without control group.
- Main Outcome
- Outcome Measure
- Inclusion criteria: Mechanism of action related to healing activity Exclusion criteria: hepatic, renal and glycemic measurements
- Additional Outcome
- Study Method
- Keyword
- Animals; Caprifoliaceae; Wound Healing
- Contact
- Adenilson Dos Santos [email protected]
- Organisational Affiliation
- Federal University of Sergipe http://www.ufs.br/
- Funding Source
- This review does not present any funding source, being carried out for the purpose of scientific research at the masters level
- Other Selection Criteria
- No restrictions will be applied as to the publication date or language.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-01-10
- Registration Date
- 2021-02-28
- Anticipated Start Date
- 2020-12-18
- Anticipated Completion Date
- 2021-04-30
- Title Cn
- Morina的愈合潜力及其体内药理特性：系统评价
- Title En
- HEALING POTENTIAL OF MORINA AND ITS PHARMACOLOGICAL PROPERTIES IN VIVO: A SYSTEMATIC REVIEW
- Bilingual Status
- complete