Meta AnalysisID 342
红曲米治疗老年人的疗效与安全性：随机临床研究的系统评价与Meta分析
CRD42020203977
What is the effect of supplementation with red yeast rice on lipids in elderly? Is supplementation with red yeast rice safe in elderly?
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Herb: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 342
- Evidence Id
- 8900
- Core Evidence Id
- 8900
- Source Meta Analysis Id
- 322
- Herb2 Meta Analysis Id
- HBMA000322
- Crd Id
- CRD42020203977
- Title
- Efficacy and safety of treatment with red yeast rice in elderly: a systematic review and meta-analysis of randomized clinical studies
- Review Question
- What is the effect of supplementation with red yeast rice on lipids in elderly? Is supplementation with red yeast rice safe in elderly?
- Study Type Included
- Inclusion criteria: (i) being a randomized controlled clinical trial with either parallel or cross-over design, (ii) enrolling subjects with a mean age at baseline >65 years, (iii) testing the effect of red yeast rice supplementation alone or in combination with other nutraceutical compounds on lipid profile, (iv) testing the safety of red yeast rice supplementation alone or in combination with other nutraceutical compounds, (v) reporting all the adverse events, (vi) having an appropriate controlled design and (vii) blinding participants to the treatment allocation. Exclusion criteria: (i) lack of randomization for treatment allocation, (ii) lack of blinding, (iii) lack of a control group receiving placebo or statin treatment, (iv) lack of sufficient information about lipids serum concentration, (v) lack of sufficient information about the prevalence and nature of the adverse events. Studies were also excluded if they contained overlapping subjects with other studies.
- Condition Being Studied
- Red yeast rice is currently one of the most commonly used lipid-lowering dietary supplements in European and Asian countries. It is produced by the fermentation of a particular yeast (in general Monascus purpureus) on rice. The yeast enriches the rice during the fermentation process with a complex of substances with important lipid-lowering activities including polyketides such as monacolins. Usually, the dietary supplements derived from red mould rice contain a concentration of monacolins of up to 1.9%. Depending on the yeast strain used and the condition of fermentation, several types of monacolins have been identified (compactin, monacolins M, L, J, X) including the subtype monacolin K, which is structurally identical to lovastatin. The main putative cholesterol-lowering mechanism of action of RYR is reversible inhibition of 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase, the key enzyme in the synthesis of cholesterol. The lipid-lowering effect of RYR has been confirmed in many available studies, including meta-analyses of randomized clinical trials. However, the effect of RYR in elderly has not been extensively evaluated until now.
- Participant
- Inclusion criteria: patients enrolled in a clinical trial and randomized to be treated with red yeast rice or a control treatment / no treatment.
- Animal
- Human Disease Modelled
- Intervention
- Red yeast rice alone or in combination with other nutraceutical compounds
- Comparator Control
- Placebo / No treatment / Alternative treatment
- Main Outcome
- Changes in total cholesterol, HDL-cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol, non HDL-cholesterol, apolipoprotein A-1, apolipoprotein B, lipoprotein(a). Assessment of the adverse events recorded during the supplementation. Measures of effect None planned
- Outcome Measure
- Additional Outcome
- None Measures of effect None planned
- Study Method
- Systematic review
- Keyword
- Aged; Biological Products; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; red yeast rice
- Contact
- Federica Fogacci [email protected]
- Organisational Affiliation
- University of Bologna http://www.medicina.unibo.it/it
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Italy
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-08-12
- Registration Date
- 2020-09-12
- Anticipated Start Date
- 2020-08-12
- Anticipated Completion Date
- 2020-10-28
- Title Cn
- 红曲米治疗老年人的疗效与安全性：随机临床研究的系统评价与Meta分析
- Title En
- Efficacy and safety of treatment with red yeast rice in elderly: a systematic review and meta-analysis of randomized clinical studies
- Bilingual Status
- complete