Meta AnalysisID 341
红曲米促进动物模型骨形成：一项系统评价与Meta分析
CRD42020170536
Does red yeast rice promote bone formation in animal models? Context and rationale Osteoporosis has brought a lot of troubles to the middle-aged and the elderly. At present, there are few drugs on the market to promote b
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Record Fields
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- Meta Analysis Id
- 341
- Evidence Id
- 8899
- Core Evidence Id
- 8899
- Source Meta Analysis Id
- 321
- Herb2 Meta Analysis Id
- HBMA000321
- Crd Id
- CRD42020170536
- Title
- Red yeast rice promotes bone formation in animal models, a systematic review and meta-analysis.
- Review Question
- Does red yeast rice promote bone formation in animal models? Context and rationale Osteoporosis has brought a lot of troubles to the middle-aged and the elderly. At present, there are few drugs on the market to promote bone formation, and some of them are expensive with high side effects. Therefore, it is necessary to explore new drugs to promote bone formation.
- Study Type Included
- Inclusion criteria: randomized controlled trial studies Exclusion criteria: non-randomized controlled trial studies
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: animal models with osteoporosis or bone loss which were ovariectomized. Exclusion criteria: animal models with other bone metabolic disease. Ex vivo, in vitro and silico models can also exclude.
- Human Disease Modelled
- Osteoporosis, a disease that affects postmenopausal women and elderly men.
- Intervention
- Inclusion criteria: feed with red yeast rice or its extraction according to weight for at least 8 weeks by oral gavage. Exclusion criteria: feed with other drugs
- Comparator Control
- Inclusion criteria: vehicle-treated control, saline control or placebo control Exclusion criteria: other control conditions that don't meet inclusion criteria
- Main Outcome
- Outcome Measure
- Inclusion criteria: bone mineral density;osteoblast proliferation;expression of alkaline phosphatase. Exclusion criteria: no relevant outcomes reported.
- Additional Outcome
- Study Method
- Keyword
- Animals; Biological Products; Models, Animal; Osteogenesis; red yeast rice
- Contact
- Lu jianhua [email protected]
- Organisational Affiliation
- Zhejiang Chinese Medical University
- Funding Source
- Funding provided by Zhejiang Chinese Medical University. Grant number(s)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- Chinese-Simplified
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-02-23
- Registration Date
- 2020-02-28
- Anticipated Start Date
- 2020-02-18
- Anticipated Completion Date
- 2020-04-18
- Title Cn
- 红曲米促进动物模型骨形成：一项系统评价与Meta分析
- Title En
- Red yeast rice promotes bone formation in animal models, a systematic review and meta-analysis.
- Bilingual Status
- complete