Meta AnalysisID 3385
褪黑素和色氨酸对接受乳腺癌治疗女性睡眠质量的影响：系统评价
CRD42022352070
Does melatonin and tryptophan supplementation interfere with sleep quality in women undergoing breast cancer treatment? Can food sources of melatonin and tryptophan modulate sleep quality in women undergoing breast cance
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Record Fields
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- Meta Analysis Id
- 3385
- Evidence Id
- 11943
- Core Evidence Id
- 11943
- Source Meta Analysis Id
- 3335
- Herb2 Meta Analysis Id
- HBMA003335
- Crd Id
- CRD42022352070
- Title
- Melatonin and tryptophan influence on sleep quality in women undergoing breast cancer treatment: a systematic review
- Review Question
- Does melatonin and tryptophan supplementation interfere with sleep quality in women undergoing breast cancer treatment? Can food sources of melatonin and tryptophan modulate sleep quality in women undergoing breast cancer treatment?
- Study Type Included
- The studies selected for the review must present as characteristics of randomized, double-blind, placebo-controlled clinical trials and present female patients undergoing breast cancer treatment as inclusion criteria. Interventions performed with breast cancer survivors, with individuals who had more than one type of cancer concomitantly, or who were using benzodiazepines as sleep inducers, will be excluded.
- Condition Being Studied
- Breast cancer is a heterogeneous group of diseases, with different behaviors. The heterogeneity of this cancer can be observed by the varied clinical and morphological manifestations, different genetic signatures and consequent differences in therapeutic responses (INCA, 2022). It is usually a therapeutic approach in breast cancer, radiotherapy and hormone therapy as part of the primary treatment, in addition to surgery. It is known that there is a change in the prevalence of insomnia during the oncological process and it is more prevalent during the treatment phase, especially during chemotherapy (PALESH et al., 2012).
- Participant
- The sample should be composed of women undergoing breast cancer treatment. Women who have another type of cancer concomitantly or who are cancer survivors will be excluded. And also, women undergoing treatment who use benzodiazepines as sleep inducers.
- Animal
- Human Disease Modelled
- Intervention
- Those interventions that, in their structure, were characterized as randomized clinical trials, with collection of data carried out through a double-blind trial, controlled by placebo and who used oral melatonin supplementation or food sources of tryptophan. Female patients undergoing breast cancer treatment will be adopted as an inclusion criterion. Interventions performed with breast cancer survivors, with subjects who had more than one type of cancer concomitantly, or who were using benzodiazepines as sleep inducers, will be excluded.
- Comparator Control
- Preferably, the intervention groups should be compared with a placebo-controlled control group. Female patients undergoing breast cancer treatment will be adopted as inclusion criteria. Breast cancer survivors and patients who had more than one type of cancer concomitantly, or who were using benzodiazepines as sleep inducers, will be excluded.
- Main Outcome
- The main results demonstrate the benefit and efficiency of the use of melatonin supplementation on the quality and total sleep time associated with the condition of breast cancer treatment. In addition, they show that the consumption of foods that precede the synthesis of melatonin (serotonin and tryptophan) can lead to an increase in circulating melatonin and a decrease in the prevalence of insomnia. To define the results, the studies are based on comparative data between the intervention and control groups, following a randomized, double-blind, placebo-controlled design.
- Outcome Measure
- Additional Outcome
- Not applicable.
- Study Method
- Intervention, Review of reviews, Systematic review
- Keyword
- Breast Neoplasms; Female; Humans; Melatonin; Sleep; Sleep Quality; Tryptophan
- Contact
- Henriqueta Vieira van Keulen [email protected]
- Organisational Affiliation
- UNIVERSIDADE FEDERAL DE JUIZ DE FORA https://www2.ufjf.br/ufjf/
- Funding Source
- The review will not receive institutional funding and will not receive funding from any private or public sponsor.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-08-14
- Registration Date
- 2022-08-25
- Anticipated Start Date
- 2022-09-01
- Anticipated Completion Date
- 2022-11-10
- Title Cn
- 褪黑素和色氨酸对接受乳腺癌治疗女性睡眠质量的影响：系统评价
- Title En
- Melatonin and tryptophan influence on sleep quality in women undergoing breast cancer treatment: a systematic review
- Bilingual Status
- complete