Meta AnalysisID 335
红曲米治疗他汀不耐受患者：随机对照研究的系统评价与Meta分析
CRD42015013298
Is red yeast rice effective for patients with dyslipidemia and statin intolerance? Is red yeast rice safe for patients with dyslipidemia and statin intolerance?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 335
- Evidence Id
- 8893
- Core Evidence Id
- 8893
- Source Meta Analysis Id
- 319
- Herb2 Meta Analysis Id
- HBMA000319
- Crd Id
- CRD42015013298
- Title
- Red yeast rice for patients with statin intolerance: systematic review and meta-analysis of randomized controlled studies
- Review Question
- Is red yeast rice effective for patients with dyslipidemia and statin intolerance? Is red yeast rice safe for patients with dyslipidemia and statin intolerance?
- Study Type Included
- Randomized controlled trials included statin-intolerant patients in which at least one group is treated with red yeast rice with known content of Monacolin K.
- Condition Being Studied
- Indication for lipid lowering therapy either because of dyslipidemia or for cardiovascular risk reduction, but unable to tolerate statin therapy.
- Participant
- Participants with an indication for lipid lowering therapy either because of dyslipidemia or for cardiovascular risk reduction, who were unable to tolerate effective doses of at least one statin because of myalgia, myopathy, myositis, or rhabdomyolysis or any other adverse effects that resolved with statin discontinuation.
- Animal
- Human Disease Modelled
- Intervention
- At least one group must be treated with red yeast rice with known content of Monacolin K. Mode of delivery: oral. No lower or upper limit on total daily dose or frequency. Studies with co-interventions such as lifestyle therapy or concomitant (herbal) medication are included, as long as the co-interventions are available for intervention as well as control group.
- Comparator Control
- Inactive (placebo) or active control treatment.
- Main Outcome
- 1) Change in LDL-cholesterol. 2) Incidence of any adverse event. Measures of effect 1) Relative (%) change of the above mentioned lipid parameter(s) compared to baseline. If change score is not mentioned in a specific study and cannot be computed, we will try to retrieve it from authors or impute it from other lipid parameters. Since monacolin K is a statin-like substance, we assume that the timing of the effect on lipid metabolism is the same as in regular statin therapy, and is likely to have a lipid lowering effect within a few weeks. Therefore, we included studies with a treatment duration of at least 4 weeks. We collect the first series of lipid outcomes after 4 weeks treatment from each study. 2) Incidence (risk) between start and end of study.
- Outcome Measure
- Additional Outcome
- 1) Change in Total cholesterol, HDL-cholesterol, Triglycerides. Measures of effect 1) Relative (%) change of the above mentioned lipid parameter(s) compared to baseline. If change score is not mentioned in a specific study and cannot be computed, we will try to retrieve it from authors or impute it from other lipid parameters. Since monacolin K is a statin-like substance, we assume that the timing of the effect on lipid metabolism is the same as in regular statin therapy, and is likely to have a lipid lowering effect within a few weeks. Therefore, we included studies with a treatment duration of at least 4 weeks. We collect the first series of lipid outcomes after 4 weeks treatment from each study.
- Study Method
- Keyword
- Biological Products; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Contact
- Organisational Affiliation
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Review Stage
- First Submission Date
- Registration Date
- Anticipated Start Date
- Anticipated Completion Date
- Title Cn
- 红曲米治疗他汀不耐受患者：随机对照研究的系统评价与Meta分析
- Title En
- Red yeast rice for patients with statin intolerance: systematic review and meta-analysis of randomized controlled studies
- Bilingual Status
- complete