Meta AnalysisID 330
褐藻马尾藻作为潜在抗炎药的体外评估：一项系统评价
CRD42023392755
Review question: Does bioactive compounds of Sargassum have an anti-inflammatory effect? PICO (Population Intervention Comparison Outcome) framework: 1) cell culture (in vitro) as a population; 2) application of extracts
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Record Fields
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- Meta Analysis Id
- 330
- Evidence Id
- 8888
- Core Evidence Id
- 8888
- Source Meta Analysis Id
- 310
- Herb2 Meta Analysis Id
- HBMA000310
- Crd Id
- CRD42023392755
- Title
- In vitro evaluation of brown algae sargassum as a potential anti-inflammatory agent: a systematic review.
- Review Question
- Review question: Does bioactive compounds of Sargassum have an anti-inflammatory effect? PICO (Population Intervention Comparison Outcome) framework: 1) cell culture (in vitro) as a population; 2) application of extracts of bioactive compounds from Sargassum as an intervention; 3) comparison of extracts of bioactive compounds from Sargassum and anti-inflammatory agents; and 4) anti-inflammatory effect as an outcome.
- Study Type Included
- The study designs that are eligible for this review is in vitro experimental studies using cell lines
- Condition Being Studied
- Brown Algae, especially Sargassum has therapeutic effects as anti-inflammatory agents. This systematic review aims at providing a comprehensive analysis of the in vitro experimental studies addressing the potential activity of bioactive compounds of Sargassum brown algae as an anti-inflammatory agent and their underlying mechanisms.
- Participant
- Cell culture (in vitro) as a population. Inclusion criteria:1) in vitro experimental studies using cell lines; 2) studies using Sargassum bioactive compound extract as an intervention; 3) studies measuring inflammatory biomarkers as an outcome; and 4) articles written in English. Exclusion criteria: 1) not original research; 2) in vivo experimental study design; (3) bioactive compounds are not isolated from marine algae, especially Sargassum; (4) inappropriate source articles (conference and proceeding papers, book chapters, and review papers); and (5) inaccessible full-text.
- Animal
- Human Disease Modelled
- Intervention
- Application of extracts of bioactive compounds from Sargassum
- Comparator Control
- Comparison of extracts of bioactive compounds from Sargassum and anti-inflammatory agents
- Main Outcome
- Some anti-inflammatory effects outcome are measured by: measuring the suppression of inflammatory responses, the production of PGE2 , TNF-a/ IL-6, production of nitric oxide (NO), and the formation of COX-2. Measures of effect Not applicable
- Outcome Measure
- Additional Outcome
- Not applicable Measures of effect Not applicable
- Study Method
- Intervention, Methodology, Narrative synthesis, Pre-clinical, Systematic review
- Keyword
- Anti-Inflammatory Agents; Cell Culture Techniques; Humans; Phaeophyta; Sargassum
- Contact
- Faisal [email protected]
- Organisational Affiliation
- Department of Oral and Maxillofacial Surgery, Faculty of Dentistry Hasanuddin University, Makassar, Indonesia. https://dent.unhas.ac.id
- Funding Source
- None Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> None
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- https://www.crd.york.ac.uk/PROSPEROFILES/392755_PROTOCOL_20230118.pdf
- Review Type
- Language
- English
- Country
- Indonesia
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-01-18
- Registration Date
- 2023-01-29
- Anticipated Start Date
- 2023-02-03
- Anticipated Completion Date
- 2023-05-09
- Title Cn
- 褐藻马尾藻作为潜在抗炎药的体外评估：一项系统评价
- Title En
- In vitro evaluation of brown algae sargassum as a potential anti-inflammatory agent: a systematic review.
- Bilingual Status
- complete