Meta AnalysisID 3244
含1%苹果酸的喷雾剂治疗口干症的疗效：一项系统评价与Meta分析
CRD42021241322
Is the spray containing 1% malic acid effective in treating various causes of xerostomia?
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Record Fields
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- Meta Analysis Id
- 3244
- Evidence Id
- 11802
- Core Evidence Id
- 11802
- Source Meta Analysis Id
- 3190
- Herb2 Meta Analysis Id
- HBMA003190
- Crd Id
- CRD42021241322
- Title
- Efficacy of a spray containing 1% malic acid in the treatment of Xerostomia: A systematic review and meta-analysis
- Review Question
- Is the spray containing 1% malic acid effective in treating various causes of xerostomia?
- Study Type Included
- Randomized controlled trials and clinical controlled trials
- Condition Being Studied
- Xerostomia is the subjective sensation of dry mouth and is usually (but not always) associated with salivary hypofunction. A drug or substance that increases the flow of saliva is called a salivary gland secretion. The condition is so common that it is often seen as a side effect of multiple medications. It is more common in older people (mainly because this group tends to take several medications) and in people who breathe through the mouth. Dehydration, radiation therapy involving the salivary glands, chemotherapy, and several diseases can lead to reduced salivary production (reduced salivary production), or changes in the consistency of the saliva, leading to xerostomia. Sometimes can not find out the specific reason, there may be psychological reasons caused. A conservative estimate of prevalence is about 20% in the general population, with increased prevalences in females (up to 30%) and the elderly (up to 50%). Estimates of the prevalence of persistent dry mouth vary between 10 and 50%.
- Participant
- Inclusion: The patient had xerostomia and was not currently taking other medications for xerostomia Exclusion: patients undergoing radiotherapy of the head and neck, chemotherapy, or maxillofacial surgery to remove all or part of the main salivary glands.
- Animal
- Human Disease Modelled
- Intervention
- Our clinical intervention applied a topical sialogogue containing 1% malic acid to treat patients for 2 weeks.
- Comparator Control
- Patients were given a placebo with the same presentation and composition (excepting malic acid).
- Main Outcome
- Dry Mouth Questionnaire (DMQ) was used to evaluate xerostomia levels before and after product/placebo application. Measures of effect MD (mean difference)
- Outcome Measure
- Additional Outcome
- As secondary measures, both unstimulated and stimulated salivary flow rates were assessed in all patients Measures of effect MD (mean difference)
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Humans; Xerostomia; malic acid
- Contact
- Gang Liu [email protected]
- Organisational Affiliation
- State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
- Funding Source
- This study was supported in part by the National Natural Science Foundation of China (81971319).
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-03-10
- Registration Date
- 2021-05-06
- Anticipated Start Date
- 2021-03-01
- Anticipated Completion Date
- 2022-02-01
- Title Cn
- 含1%苹果酸的喷雾剂治疗口干症的疗效：一项系统评价与Meta分析
- Title En
- Efficacy of a spray containing 1% malic acid in the treatment of Xerostomia: A systematic review and meta-analysis
- Bilingual Status
- complete