Meta AnalysisID 3202
氧化镁治疗慢性便秘：一项系统评价与Meta分析
CRD42022296375
Chronic constipation is a prevalent, burdensome gastrointestinal disorder whose treatment remains challenging. Magnesium oxide has been used as a permeable laxative in the treatment of constipation for a long time, but i
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3202
- Evidence Id
- 11760
- Core Evidence Id
- 11760
- Source Meta Analysis Id
- 3150
- Herb2 Meta Analysis Id
- HBMA003150
- Crd Id
- CRD42022296375
- Title
- Magnesium Oxide for chronic constipation: a systemic review and meta-analysis
- Review Question
- Chronic constipation is a prevalent, burdensome gastrointestinal disorder whose treatment remains challenging. Magnesium oxide has been used as a permeable laxative in the treatment of constipation for a long time, but its safety and efficacy have not been systematically reviewed. Therefore, we performed meta-analyses to evaluate the efficacy of Magnesium Oxide in the treatment of chronic constipation.
- Study Type Included
- Only randomized controlled trials (RCTs) will be included in this study. Nonrandomized controlled studies case reports, case series and reviews will not be included in this study.
- Condition Being Studied
- Epidemiology shows that the global prevalence of functional constipation in adults is10.1%. Although constipation is not life-threatening, it may directly or indirectly increase the probability of other mental or physical illnesses. Its impact on the life quality may be as great as other chronic diseases. Due to the severity and high prevalence, constipation put a considerable burden on health care resources. Magnesium oxide has been used as a permeable laxative in the treatment of constipation for a long time, but its safety and efficacy have not been systematically reviewed. Therefore, we performed meta-analyses to evaluate the efficacy of Magnesium Oxide in the treatment of chronic constipation.
- Participant
- Children and adults who met the Rome-III or IV Criteria were included in the study. Patients with other organic diseases will be excluded. 1 (Must have ≥2 the following criteria for ≥3months 1）≤2 defaecationsin the toilet per week; 2）Lumpy or hard stools more than 25% of defaecations; 3）Straining during more than 25% of defaecations; 4）Sensation of incomplete evacuation more than 25% of defaecations; 5）Sensation of anorectal obstruction/blockage more than 25% ofdefaecations; 6）Manual manoeuvresto facilitate more than 25% of defaecations) 2. Loose stools are rarely present without the use of laxatives 3. Insufficient criteria for irritable bowel syndrome Criteria fulfilled for the last 3 months with symptom onset at least 6 months prior to diagnosis.
- Animal
- Human Disease Modelled
- Intervention
- patient treat with Magnesium Oxide, which is an Osmotic laxative used to treat constipation.
- Comparator Control
- The control interventions could be no treatment, another active treatment or medication.
- Main Outcome
- The primary outcome measure will be the frequency of bowel movement, which is defined as the mean number of spontaneous bowel movements per week. Measures of effect The odds ratio (OR) and the corresponding 95% confidence interval (Bayesian equivalent of the 95% confidence interval (CI)) were used to summarize and compare the different efficacy and adverse effects of different treatments.
- Outcome Measure
- Additional Outcome
- Safety and risk Measures of effect The odds ratio (OR) and the corresponding 95% confidence interval (Bayesian equivalent of the 95% confidence interval (CI)) were used to summarize and compare the different efficacy and adverse effects of different treatments.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Constipation; Humans; Laxatives; Magnesium Oxide
- Contact
- Mengen Zhou [email protected]
- Organisational Affiliation
- Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-12-05
- Registration Date
- 2022-01-05
- Anticipated Start Date
- 2021-12-30
- Anticipated Completion Date
- 2022-02-28
- Title Cn
- 氧化镁治疗慢性便秘：一项系统评价与Meta分析
- Title En
- Magnesium Oxide for chronic constipation: a systemic review and meta-analysis
- Bilingual Status
- complete