Meta AnalysisID 3175
纳米级营养素递送系统对叶黄素体内生物利用度的影响：文献系统评价
CRD42020168592
In rodent models, how does nanoscale nutrient delivery system compared to un-encapsulated lutein affect the bioavailability and functionalities of lutein? P: Rodent models I: lutein with nanoencapsulation techniques that
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- Meta Analysis Id
- 3175
- Evidence Id
- 11733
- Core Evidence Id
- 11733
- Source Meta Analysis Id
- 3124
- Herb2 Meta Analysis Id
- HBMA003124
- Crd Id
- CRD42020168592
- Title
- The impact of nanoscale nutrient delivery systems on in vivo bioavailability of lutein: a systematic review of literatures
- Review Question
- In rodent models, how does nanoscale nutrient delivery system compared to un-encapsulated lutein affect the bioavailability and functionalities of lutein? P: Rodent models I: lutein with nanoencapsulation techniques that meet the definition of nanoscale nutrient delivery system C: Unencapsulated lutein, such as lutein powder or physical mixtures O: Bioavailability of lutein in animal models S: In vivo studies Context and rationale Lutein, a phytochemical belonging to the large class of plant pigments known as carotenoids, is a potent scavenger of free radicals due to its polarity and number of conjugated double bonds. It cannot be synthesized de novo in animals and must be obtained from diet. In the body, lutein acts as a powerful antioxidant that accumulates in the retina, particularly the macular region, and it is the main component of the macular pigment. In the eye, lutein protects the macula from light-initiated oxidative damage. However, the application of lutein in food and medicine is limited due to its poor water solubility, poor light stability and high temperature stability and low bioavailability. Nanoscale nutrient delivery systems are novel technologies that have been widely used in food science to improve the stability of lipophilic nutrients, vitamins, and nutraceuticals. Most studies have tested the effectiveness of the nanoscale nutrient delivery system only in vitro, while some have tested the effectiveness and safety of increasing lutein bioavailability in animal models. To our knowledge, this is the first systematic evaluation of the effectiveness of this new technique in vivo studies. Only rodent models that are highly similar to human metabolic pathways are reviewed. This system reviews the application of basic nutrition in clinical nutrition and helps researchers identify the most effective nanoscale drug delivery systems for improving the bioavailability of lutein, thus contributing to the prevention of lutein deficiency related diseases.
- Study Type Included
- Inclusion criteria: 1. Controlled studies with a separate control group Exclusion criteria: 1. Studies without a separate control group
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: 1. In vivo 2. Rodent models 2. Using oral dosing as the way of administration. Exclusion criteria: 1. Other animal models besides rodent models 2. Ex vivo 2. Use other methods of administration, such as topical injections
- Human Disease Modelled
- The condition being modeled is the bioavailability of lutein. Bioavailability, which can be defined as the proportion of administrated substances that can be absorbed and made available for use or storage, is an important parameter to determine the effectiveness of the dietary supplement to be utilized by human body. Bioavailability of lutein were evaluated to determine the effectiveness of lutein using nanoscale nutrient delivery system.
- Intervention
- Inclusion criteria: 1. Animal model should be given effective dosage, as measured by the plasma and organ concentration of lutein. 2. Treatment with lutein and nanoscale nutrient delivery system Exclusion criteria: 1. Studies that did not use lutein as the only intervention nutrient. 2. Studies did not use the nanoscale nutrient delivery systems
- Comparator Control
- Inclusion criteria: 1. Must have at least one control group, such as using physical mixture or pure lutein as the control groups. Exclusion criteria: 1. Only contain the treatment group.
- Main Outcome
- Outcome Measure
- Inclusion criteria: 1. Bioavailability, defined as the proportion of administrated substances that can be absorbed and made available for use or storage (%), or a significantly increased of lutein concentration in plasma as compared to control group (unit: umol/L) 2. Encapsulation efficacy (EE%) to calculate the content of lutein in the nanoencapsulation Exclusion criteria: 1. Only test the stability of samples or other chemical properties of the nanoscale nutrient delivery system 2. Not relevant outcome measure reported
- Additional Outcome
- Study Method
- Keyword
- Animals; Biological Availability; Lutein; Nutrients
- Contact
- Yanqi Zhang [email protected]
- Organisational Affiliation
- University of Alabama
- Funding Source
- Other Selection Criteria
- Inclusion: all publication dates. Exclusion criteria: Non-english articles
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Experimental animal exposure review
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-02-11
- Registration Date
- 2020-02-14
- Anticipated Start Date
- 2020-01-30
- Anticipated Completion Date
- 2020-06-30
- Title Cn
- 纳米级营养素递送系统对叶黄素体内生物利用度的影响：文献系统评价
- Title En
- The impact of nanoscale nutrient delivery systems on in vivo bioavailability of lutein: a systematic review of literatures
- Bilingual Status
- complete