Meta AnalysisID 3159
静脉注射布洛芬赖氨酸盐与布洛芬氨丁三醇盐用于早产儿动脉导管未闭闭合的有效性和安全性比较：一项系统评价与网状Meta分析
CRD42021273018
In preterm or low birth weight neonates with clinical and/or echocardiographically diagnosed patent ductus arteriosus, how effective is intravenous ibuprofen lysine salt when indirectly compared to intravenous ibuprofen
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3159
- Evidence Id
- 11717
- Core Evidence Id
- 11717
- Source Meta Analysis Id
- 3108
- Herb2 Meta Analysis Id
- HBMA003108
- Crd Id
- CRD42021273018
- Title
- Comparative effectiveness and safety of intravenous ibuprofen lysine salt versus ibuprofen tromethamine salt for patent ductus arteriosus closure in preterm infants: A systematic review and network meta-analysis.
- Review Question
- In preterm or low birth weight neonates with clinical and/or echocardiographically diagnosed patent ductus arteriosus, how effective is intravenous ibuprofen lysine salt when indirectly compared to intravenous ibuprofen tromethamine salt at closing such patent ductus arteriosus?
- Study Type Included
- Randomized controlled trials
- Condition Being Studied
- Management of persistent patent ductus arteriosus (PDA) in preterm infants is a controversial topic in neonatal medicine. Previously studied management questions have centered around when and how to treat significant PDA. There have been a large number of published studies, meta-analysis, reviews focusing on different management approaches and outcomes. Ibuprofen is commonly used for prophylaxis and treatment of significant PDA, along with other therapeutic measures including indomethacin and acetaminophen. Ibuprofen is as effective and economical as indomethacin in closing PDA and in comparison, reduces the risk of associated complications including NEC and renal insufficiency. A question persists among the Neonatology sphere as to the variability of efficacy and associated risks of clinically relevant ibuprofen salts. At present, no direct randomized control trials have directly compared the two most commonly used IV ibuprofen salts, lysine and tromethamine (THAM). In current literature, neonates treated with ibuprofen lysine had improved renal outcomes when compared to neonates treated with indomethacin. Furthermore, IV ibuprofen lysine was suggested to be at least as effective as indomethacin for PDA closure, while IV ibuprofen THAM was associated with higher rates of comorbidity. This study aims to indirectly compare outcomes of treatment with both ibuprofen salts.
- Participant
- Preterm or low birth weight neonates with clinical and/or echocardiographically diagnosed PDA
- Animal
- Human Disease Modelled
- Intervention
- Intravenous ibuprofen lysine salt OR Intravenous ibuprofen tromethamine salt
- Comparator Control
- Any other interventions or placebo
- Main Outcome
- Main outcome(s): Closure of PDA Secondary outcome(s): -Incidence of repeat pharmacologic therapy for symptomatic PDA -Incidence of interventional PDA closure -Incidence of necrotizing enterocolitis -Incidence of bronchopulmonary dysplasia -Incidence of intraventricular hemorrhage -Incidence of severe intraventricular hemorrhage -Incidence of oliguria -Incidence of neurodevelopmental disability (data may be insufficient to report network) -Incidence of mortality Measures of effect Risk ratios and risk differences (categorical variables), and mean differences (continuous variables)
- Outcome Measure
- Additional Outcome
- Study Method
- Network meta-analysis, Systematic review
- Keyword
- Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant, Newborn; Infant, Premature; Lysine; Network Meta-Analysis; Tromethamine
- Contact
- Tess Robart [email protected]
- Organisational Affiliation
- Dalhousie Pediatrics
- Funding Source
- None Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> None
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Canada
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-08-11
- Registration Date
- 2021-09-11
- Anticipated Start Date
- 2021-03-01
- Anticipated Completion Date
- 2022-03-01
- Title Cn
- 静脉注射布洛芬赖氨酸盐与布洛芬氨丁三醇盐用于早产儿动脉导管未闭闭合的有效性和安全性比较：一项系统评价与网状Meta分析
- Title En
- Comparative effectiveness and safety of intravenous ibuprofen lysine salt versus ibuprofen tromethamine salt for patent ductus arteriosus closure in preterm infants: A systematic review and network meta-analysis.
- Bilingual Status
- complete