Meta AnalysisID 3146
锂盐治疗对钙和甲状旁腺激素浓度的影响：系统评价与Meta分析
CRD42021241339
In which degree does lithium treatment increase calcium and parathyroid hormone plasma concentrations?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3146
- Evidence Id
- 11704
- Core Evidence Id
- 11704
- Source Meta Analysis Id
- 3095
- Herb2 Meta Analysis Id
- HBMA003095
- Crd Id
- CRD42021241339
- Title
- Lithium treatment effects on calcium and parathyroid hormone concentrations: a systematic review and meta-analysis
- Review Question
- In which degree does lithium treatment increase calcium and parathyroid hormone plasma concentrations?
- Study Type Included
- Double-blind clinical trials using any pharmacological comparator (placebo or other drugs) will be included. Longitudinal open-label trials (with or without comparator group) and case series of at least 5 participants will also be included.
- Condition Being Studied
- Changes in calcium and parathyroid hormone concentrations after starting lithium therapy
- Participant
- Patients with a psychiatric diagnosis (bipolar disorder, schizoaffective disorder, major depression and other psychiatric diagnoses) receiving lithium therapy
- Animal
- Human Disease Modelled
- Intervention
- Lithium treatment
- Comparator Control
- All studies including repeated measures (baseline and follow-up) in calcium or PTH will be considered. Controlled (placebo or other drugs) and uncontrolled trials will be included in the systematic review. Randomised, controlled clinical trials will be included in the meta-analysis.
- Main Outcome
- Change in calcium plasma concentrations from baseline to the last available follow-up. Measures of effect Standardized mean differences (Hedges' g)
- Outcome Measure
- Additional Outcome
- Change in parathyroid hormone plasma concentrations from baseline to the last available follow-up. Development of hypercalcemia after starting lithium therapy. Measures of effect Change in parathyroid hormone plasma concentrations: Standardized mean differences (Hedges' g) Development of hypercalcemia: proportion (all studies) and odds ratio (randomised, controlled trials).
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Calcium; Humans; Lithium; Lithium Compounds; Parathyroid Hormone
- Contact
- Javier Labad [email protected]
- Organisational Affiliation
- Psychoneuroendocrinology Workgroup from the Societat Catalana de Psiquiatria i Salut Mental (PNECAT) http://webs.academia.cat/societats/psiquia/?p=page/html/g-psiconeu
- Funding Source
- Generalitat de Catalunya - Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> 2017SGR632
- Other Selection Criteria
- Final Publication
- Same Topic Review
- There is no previous review on this topic by our group.
- Published Protocol
- Review Type
- Language
- English
- Country
- Spain
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-03-07
- Registration Date
- 2021-04-07
- Anticipated Start Date
- 2021-03-14
- Anticipated Completion Date
- 2022-02-28
- Title Cn
- 锂盐治疗对钙和甲状旁腺激素浓度的影响：系统评价与Meta分析
- Title En
- Lithium treatment effects on calcium and parathyroid hormone concentrations: a systematic review and meta-analysis
- Bilingual Status
- complete