Meta AnalysisID 3086
心脏再同步化治疗中左心室导线的靶向定位：一项系统评价和Meta分析
CRD42022355716
Does targeted positioning of the LV lead to the site of latest activation provide superior clinical outcomes or cardiac function improvement compared to routine positioning in patients with cardiac resynchronization ther
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3086
- Evidence Id
- 11644
- Core Evidence Id
- 11644
- Source Meta Analysis Id
- 3037
- Herb2 Meta Analysis Id
- HBMA003037
- Crd Id
- CRD42022355716
- Title
- Targeted positioning of the left ventricular lead in cardiac resynchronization therapy; a systematic review and meta-analysis
- Review Question
- Does targeted positioning of the LV lead to the site of latest activation provide superior clinical outcomes or cardiac function improvement compared to routine positioning in patients with cardiac resynchronization therapy?
- Study Type Included
- Randomized controlled trials and follow-up on mid-to-long-term outcomes from randomized controlled trials will be included. Single-arm prospective trials, cohort studies, case-control studies and case reports will be excluded.
- Condition Being Studied
- Cardiac resynchronization therapy in heart failure.
- Participant
- Adult patients with heart failure who underwent CRT implantation.
- Animal
- Human Disease Modelled
- Intervention
- Implantation of CRT can improve cardiac function and reduce mortality, morbidity, and symptoms in patients with heart failure and left bundle branch block with prolonged QRS duration, by resynchronizing ventricular contraction. However, up to 30% of CRT recipients derive no measurable clinical benefit. Targeted positioning of the left ventricular (LV) lead to the site of latest activation may provide more effective resynchronization and has been suggested to further improve clinical response compared to routine LV lead positioning. The intervention group will include patients who underwent CRT implantation with targeted positioning of the LV lead to the site of latest activation. Targeting can be achieved using either imaging modalities (latest mechanical activation) or electrophysiological mapping (latest electrical activation).
- Comparator Control
- The control group include patients who underwent CRT implantation with routine positioning of the LV lead, or targeted LV lead positioning with a different modality than the intervention group.
- Main Outcome
- All-cause mortality, cardiovascular death, and heart failure hospitalization Measures of effect For categorical variables effect will be measured as relative risks, odds ratios or hazard ratios
- Outcome Measure
- Additional Outcome
- Improvement in New York Heart Association (NYHA) functional class, improvement in 6-minute walk test (6MWT) distance, patient-reported quality of life and additional improvement in LV ejection fraction (EF), reduced LV end-systolic volume (ESV), and LV end-diastolic volume (EDV) as assessed by echocardiography. Measures of effect For categorical variables effect will be measured as relative risks, odds ratios or hazard ratios. For continuous variables effects will be measured as mean differences or standardized mean differences
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Humans
- Contact
- Henrik Laurits Bjerre [email protected]
- Organisational Affiliation
- Aarhus University Hospital
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Denmark
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-08-24
- Registration Date
- 2022-09-04
- Anticipated Start Date
- 2022-09-01
- Anticipated Completion Date
- 2023-03-01
- Title Cn
- 心脏再同步化治疗中左心室导线的靶向定位：一项系统评价和Meta分析
- Title En
- Targeted positioning of the left ventricular lead in cardiac resynchronization therapy; a systematic review and meta-analysis
- Bilingual Status
- complete