Meta AnalysisID 3085
血铅水平与慢性肾脏病标志物的关联：一项更新的系统评价和Meta分析
CRD42022354202
To study the association between Blood Lead Levels and markers of chronic kidney disease by performing systematic review and meta-analysis
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Record Fields
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- Meta Analysis Id
- 3085
- Evidence Id
- 11643
- Core Evidence Id
- 11643
- Source Meta Analysis Id
- 3036
- Herb2 Meta Analysis Id
- HBMA003036
- Crd Id
- CRD42022354202
- Title
- Association between Blood Lead Levels and markers of chronic kidney disease: An updated systematic review and meta-analysis.
- Review Question
- To study the association between Blood Lead Levels and markers of chronic kidney disease by performing systematic review and meta-analysis
- Study Type Included
- Observational studies
- Condition Being Studied
- Lead is regarded as an industrial pollutant, its profuse use recognizes as an environmental pollutant. A recent SRMA demonstrated aberrations in thyroid hormone balance, calcium homeostasis, male reproductive hormones, immunotoxicity, and genotoxicity due to chronic Pb exposure. The burden of chronic renal dysfunction/failure increased by 2 fold since 1990. The association between chronic Pb exposure and kidney damage was historically established in occupationally exposed individuals. Chronic lead exposure is associated with glomerular sclerosis and interstitial fibrosis. Recent review demonstrated impaired clearance of creatinine and blood urea nitrogen among chronically Pb-exposed adults. Based on the site of insult, chronic renal failure is pathophysiologically categorized as tubulointerstitial, glomerular, and endothelial. The site of injury is identified by demonstrating specific biomarkers, viz N-acetyl-β-O-glucosaminidase (NAG), Kidney Injury Molecule (KIM)-1, neutrophil gelatinase-associated lipocalin (NGAL), liver-type fatty acid-binding protein (L-FABP) for tubulointerstitial injury, podocin, nephrin and podocalyxin for glomerular injury, asymmetric dimethylarginine (ADMA) for endothelial dysfunction and Cystatin-C, β-Trace protein for glomerular filtration function. Current study proposes to investigate the potential site of injury in the kidney due to chronic Pb exposure by systematically reviewing the existing literature reporting the changes in these markers among occupationally Pb exposed workers as compared to those without obvious occupational Pb exposure.
- Participant
- Studies reporting BLL and markers of chronic kidney disease among occupationally lead exposed and unexposed workers. Exclusion criteria: Animal studies Cell line studies Acute lead poisoning Studies involving participants with congenital / acquired disorders of kidney diseases.
- Animal
- Human Disease Modelled
- Intervention
- Occupationally exposed to Lead.
- Comparator Control
- Adults without occupational Pb exposure
- Main Outcome
- Cystatin C, β-Trace protein, e-GFR, NGAL, KIM-1, NAG, L-FABP, Podocin, Nephrin, Podocalyxin, ADMA
- Outcome Measure
- Additional Outcome
- Study Method
- Epidemiologic, Systematic review
- Keyword
- Humans; Lead; Renal Insufficiency, Chronic
- Contact
- Kuldip Upadhyay [email protected]
- Organisational Affiliation
- ICMR-National Institute of Occupational Health
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- India
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-08-17
- Registration Date
- 2022-08-28
- Anticipated Start Date
- 2022-08-18
- Anticipated Completion Date
- 2023-02-07
- Title Cn
- 血铅水平与慢性肾脏病标志物的关联：一项更新的系统评价和Meta分析
- Title En
- Association between Blood Lead Levels and markers of chronic kidney disease: An updated systematic review and meta-analysis.
- Bilingual Status
- complete