Meta AnalysisID 3081
妊娠期铅暴露与子痫前期风险的相关性
CRD42022347220
How does lead exposure affect maternal risk of preeclampsia?
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Record Fields
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- Meta Analysis Id
- 3081
- Evidence Id
- 11639
- Core Evidence Id
- 11639
- Source Meta Analysis Id
- 3032
- Herb2 Meta Analysis Id
- HBMA003032
- Crd Id
- CRD42022347220
- Title
- Correlation Between Lead Exposure and Risk of Preeclampsia during pregnancy
- Review Question
- How does lead exposure affect maternal risk of preeclampsia?
- Study Type Included
- Prospective or retrospective observational studies
- Condition Being Studied
- Preeclampsia complicates around 2-10% of all pregnancies worldwide. In lower-middle-income countries (LMICs), the incidence has increased despite some measures taken to prevent this disease. Preeclampsia still accounts for the leading causes of maternal and perinatal morbidity and mortality in the developing world. There are many pieces of research on the risk factors for preeclampsia across different genetic and ethnic backgrounds. However, heavy metals could also have an impact on the risks of developing hypertensive disorders in pregnancy. Lead was associated with the inflammatory and toxic response in the human body. This could sequentially lead to preeclampsia in some women. In this sense, lead exposure may implicate the risks of preeclampsia. Research by far reports controversial results on its levels and association with preeclampsia. Therefore, we want to include all the articles available now to draw the conclusion between lead exposure and preeclampsia.
- Participant
- We included all the studies that focus on pregnant women. Normotensive uncomplicated pregnancies reported in the respective publication were considered as control groups. Published studies were eligible for inclusion if they reported lead exposure and in women with or without preeclampsia. Exclusion criteria: PE, lead exposure data were not available or could not be extracted from the study groups; no appropriate control group
- Animal
- Human Disease Modelled
- Intervention
- The study group should have accurate data on lead exposure.
- Comparator Control
- The control group is the normotensive pregnant women in respective studies with accurate data on lead exposure.
- Main Outcome
- The relative risk, severity and onset of preeclampsia.
- Outcome Measure
- Additional Outcome
- pre-term delivery, maternal ICU admission, NICU admission
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Female; Humans; Lead; Pre-Eclampsia; Pregnancy; Risk Factors
- Contact
- Zixing Zhong [email protected]
- Organisational Affiliation
- Zhejiang Provincial People's Hospital www.hospitalstar.com
- Funding Source
- Zhejiang Provincial Project for Medical and Health Science and Technology Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> Grant No. 2022503241, Jan 1st 2022
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-07-18
- Registration Date
- 2022-07-28
- Anticipated Start Date
- 2022-07-18
- Anticipated Completion Date
- 2022-08-19
- Title Cn
- 妊娠期铅暴露与子痫前期风险的相关性
- Title En
- Correlation Between Lead Exposure and Risk of Preeclampsia during pregnancy
- Bilingual Status
- complete