Meta AnalysisID 3027
多巴胺治疗危重症成人患者心功能障碍：一项系统评价、Meta分析及试验序贯分析
CRD42016042867
The objective is to perform a systematic review with meta-analyses and Trial Sequential Analyses (TSA) of randomised clinical trials (RCTs) according to The Cochrane Handbook for Systematic Reviews of Interventions and T
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3027
- Evidence Id
- 11585
- Core Evidence Id
- 11585
- Source Meta Analysis Id
- 2978
- Herb2 Meta Analysis Id
- HBMA002978
- Crd Id
- CRD42016042867
- Title
- Dopamine for cardiac dysfunction in critically ill adult patients: a systematic review with meta-analysis and trial sequential analysis
- Review Question
- The objective is to perform a systematic review with meta-analyses and Trial Sequential Analyses (TSA) of randomised clinical trials (RCTs) according to The Cochrane Handbook for Systematic Reviews of Interventions and The Cochrane Hepato-Biliary Group Module comparing the benefits and harms of dopamine versus placebo, no intervention, or other inotropes in adult critically ill patients with cardiac dysfunction.
- Study Type Included
- We will consider all RCT’s for inclusion irrespective of language, blinding, publication status, or sample size for assessment of benefits and harms. Quasi-randomised studies (where the method of allocating participants to a treatment are not strictly random, for example, date of birth, hospital record number, alternation) and observational studies will not be included regarding assessment of benefits. RCT’s may report some of the harms of an intervention, either those which were expected and which the trial was designed to assess, or those which were not expected but which were collected in the trial as part of standard monitoring of safety. However, many serious harms of an intervention are too rare or do not appear during the follow-up period of randomised clinical trials, and therefore will not be reported. To assess (potential unexpected or rare) harms of interventions we will also include quasi-randomised and observational studies, but the results will be analysed separately.
- Condition Being Studied
- Critically ill patients. Mortality and adverse events.
- Participant
- Only trials with adult critically ill patients with cardiac dysfunction will be included. Cardiac dysfunction was defined as a left ventricular ejection fraction (LVEF) below 45% and/or a low cardiac output syndrome. Low cardiac output syndrome was defined as a pre-existing or developing state of cardiac insufficiency with underlying left or right ventricular systolic dysfunction requiring inotrope support (36,37). Since cardiac surgery, cardiology and critically ill patients will be included we anticipate that heterogeneity will be present in the patient populations.
- Animal
- Human Disease Modelled
- Intervention
- Dopamine will be the experimental intervention. There will be no restrictions on dose or duration of dopamine administration. Studies with oral administration of dopamine may be used in outpatients settings, but are not applicable to critically ill patients and will therefore be excluded.
- Comparator Control
- Studies will be included irrespective of the control interventions, i.e. dopamine compared with: •
- Main Outcome
- Outcome Measure
- Additional Outcome
- Study Method
- Systematic review
- Keyword
- Adult; Critical Illness; Dopamine; Humans
- Contact
- Organisational Affiliation
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Review Stage
- First Submission Date
- Registration Date
- Anticipated Start Date
- Anticipated Completion Date
- Title Cn
- 多巴胺治疗危重症成人患者心功能障碍：一项系统评价、Meta分析及试验序贯分析
- Title En
- Dopamine for cardiac dysfunction in critically ill adult patients: a systematic review with meta-analysis and trial sequential analysis
- Bilingual Status
- complete