Meta AnalysisID 2988
益生菌和益生元用于成人乳糖不耐受的对症治疗：系统评价与Meta分析
CRD42022295691
Which strains of microorganisms are most effective in improving symptoms of LI in adults?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2988
- Evidence Id
- 11546
- Core Evidence Id
- 11546
- Source Meta Analysis Id
- 2938
- Herb2 Meta Analysis Id
- HBMA002938
- Crd Id
- CRD42022295691
- Title
- Probiotics and prebiotics in the symptomatic treatment of lactose intolerance in adults: a systematic review and meta-analysis
- Review Question
- Which strains of microorganisms are most effective in improving symptoms of LI in adults?
- Study Type Included
- The inclusion criteria are: - being a randomised placebo-controlled clinical trial; - addressing the issue of lactose intolerance associated with the use of probiotics of any kind; - being a study with human participants; - being performed with adults; - being in scientific article format; - having free access to read the full text; - having good methodological quality assessed by RoB 2.0. The exclusion criteria are: - studies with non-randomised designs; - studies not reporting on the effect of probiotics and prebiotics in patients with lactose intolerance - being a study in the form of videos, books; - being a repeated study; - being a study with animals; - being a study with children; - not being a free-access article for full reading; - including patients with chronic, infectious, or other illnesses.
- Condition Being Studied
- Lactose intolerance is a condition when occurred a decrease in the production of lactase enzyme. As a consequence of this, when consuming certain quantities of products containing lactose, the characteristic symptoms of this condition appear. Among the symptoms are diarrhoea, abdominal pain, flatulence, stomach pains, vomiting, and headaches. In this sense, probiotics and prebiotics have stood out as an alternative method of recomposing the intestinal microbiota, minimizing the symptoms caused by malabsorption of lactose.
- Participant
- Adults of all genders with a confirmed diagnosis of lactose intolerance, who have participated in a RCT that examined the effects of probiotics and prebiotics in this condition.
- Animal
- Human Disease Modelled
- Intervention
- Supplementation of any probiotics and/or prebiotics as prevention, control or treatment of Lactose Intolerance symptoms. Interventions can be simultaneous or asynchronous.
- Comparator Control
- Subgroup analyses should be conducted with a placebo group, with standard treatment with lactase enzymes or alternative supplementation or medicine. The placebo group or control group must have similar characteristics to the intervention group.
- Main Outcome
- Improvement of clinical symptoms, measured either by self-reported measures and/or by biochemical or microbiological measures chosen and described in the RCT. Measures of effect Odds ratio (95% confidence intervals) for the association between being in the intervention group with prebiotics and probiotics and improvement in clinical symptoms; Odds ratio (95% confidence intervals) for the association between being in the intervention group with prebiotics and probiotics and improvement in biochemical or microbiological measures;
- Outcome Measure
- Additional Outcome
- Relief of abdominal pain, bowel distension, flatulence, diarrhoea, constipation, nausea, and vomiting; or other systemic symptoms, such as headaches, dizziness, among others that may be reported in the RCT.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Adult; Humans; Lactose Intolerance; Prebiotics; Probiotics
- Contact
- Luiza Scalcon de Oliveira [email protected]
- Organisational Affiliation
- UNIOESTE – Western Paraná State University Street: Vitório Traiano, Km 2, City: Francisco Beltrão/ State/Province: Paraná / Postal/Zip Code: 85601-970 / Country: Brazil
- Funding Source
- CAPES - Coordination of Superior Level Staff Improvement
- Other Selection Criteria
- Final Publication
- Oliveira L. S., Wendt G. W., Crestani A. P. J., Casaril, K. B. P. B. The use of probiotics and prebiotics can enable the ingestion of dairy products by lactose intolerant individuals, Clinical Nutrition [Internet] 2022 Dec; 41(12):2644-2650, ISSN 0261-5614, https://doi.org/10.1016/j.clnu.2022.10.003. Available from: https://www.ScienceDirect.com/science/article/pii/S0261561422003545. https://www.ScienceDirect.com/science/article/abs/pii/S0261561422003545?dgcid=author
- Same Topic Review
- not applicable
- Published Protocol
- Review Type
- Language
- English, Portuguese-Brazil, Spanish
- Country
- Brazilnot applicable
- Review Stage
- Review Completed published
- First Submission Date
- 2021-12-01
- Registration Date
- 2022-01-01
- Anticipated Start Date
- 2021-12-02
- Anticipated Completion Date
- 2022-10-01
- Title Cn
- 益生菌和益生元用于成人乳糖不耐受的对症治疗：系统评价与Meta分析
- Title En
- Probiotics and prebiotics in the symptomatic treatment of lactose intolerance in adults: a systematic review and meta-analysis
- Bilingual Status
- complete