Meta AnalysisID 2985
无乳糖牛奶和乳制品的健康影响——随机对照试验的系统评价
CRD42019135388
Lactose is a fermentable short-chain carbohydrate that is poorly absorbed in many individuals and restriction or elimination from the diet can improve gastrointestinal symptoms to promote nutritional status and quality o
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Record Fields
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- Meta Analysis Id
- 2985
- Evidence Id
- 11543
- Core Evidence Id
- 11543
- Source Meta Analysis Id
- 2935
- Herb2 Meta Analysis Id
- HBMA002935
- Crd Id
- CRD42019135388
- Title
- Health effects of lactose-free milk and dairy products – a systematic review of randomised controlled trials
- Review Question
- Lactose is a fermentable short-chain carbohydrate that is poorly absorbed in many individuals and restriction or elimination from the diet can improve gastrointestinal symptoms to promote nutritional status and quality of life, particularly in people with lactose intolerance. Therefore, the review question is: In humans, what are the effects of consuming lactose-free milk and dairy products on health outcomes in comparison to control conditions (including lactose containing milk) in individuals of all ages and health status? The objective is to consolidate the evidence from randomised controlled trials surrounding the positive, neutral or negative responses to lactose-free milk and dairy products on all health-related outcomes, but in particular gut health, gut microbiome, gut microbiota, and microbiota diversity.
- Study Type Included
- We will include randomised controlled trials and crossover trials where placebo or control, which may contain lactose, is used as the comparison group. Only studies with sample sizes over five participants will be included, that reported the baseline and post-intervention levels of health-related and gastrointestinal outcomes using at least one previously validated assessment or analysis method.
- Condition Being Studied
- Populations of interest include healthy individuals and people with lactose intolerance or malabsorption. Outcomes of interest include the hydrogen breath test, blood-based biomarkers such as blood glucose levels, and the urine galactose test, human stool and microbiome sampling, and other urine analysis.
- Participant
- Populations of interest include healthy individuals and people with lactose intolerance or malabsorption. Included: Individuals of all ages, without regard to gender, race or ethnicity. Articles published before July 2019 will be assessed to determine if they meet the inclusion criteria. Excluded: observational, in vitro, in silico and animal studies.
- Animal
- Human Disease Modelled
- Intervention
- Acute and/or chronic consumption or supplementation with lactose-free milk or dairy products alone or as part of a functional food product that is lactose-free.
- Comparator Control
- Placebo or control groups.
- Main Outcome
- Differences in the hydrogen breath test commonly used to evaluate the malabsorption of lactose. Measures of effect Acute and chronic studies to evaluate short and long-term effects will be included.
- Outcome Measure
- Additional Outcome
- Secondary outcomes include changes in blood-based biomarkers such as blood glucose levels, and the urine galactose test, human stool and microbiome sampling, and other urine analysis. The results of other quantitative measures such as health-related quality of life and the Lactose Intolerance Questionnaire will also be synthesised and analysed. Measures of effect Acute and chronic studies to evaluate short and long-term effects will be included.
- Study Method
- Intervention, Narrative synthesis, Systematic review
- Keyword
- Humans; Lactose; Lactose Intolerance; Milk
- Contact
- Nenad Naumovski [email protected]
- Organisational Affiliation
- University of Canberra www.canberra.edu.au
- Funding Source
- This project is funded by Capitol Chilled Foods Australia PTY/LTD (Canberra Milk); however, the funder does not have any role in the design of the study, collection and analysis or interpretation of the data. The funder will also not have any role in the writing of the manuscript or in the decision to publish the results.
- Other Selection Criteria
- Final Publication
- Sharp E, D'Cunha NM, Ranadheera CS, Vasiljevic T, Panagiotakos DB, Naumovski N. Effects of lactose-free and low-lactose dairy on symptoms of gastrointestinal health: A systematic review. International Dairy Journal. 2021;114:104936. https://doi.org/10.1016/j.idairyj.2020.104936
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Australia
- Review Stage
- Review Completed published
- First Submission Date
- 2019-05-14
- Registration Date
- 2019-07-11
- Anticipated Start Date
- 2019-06-30
- Anticipated Completion Date
- 2020-03-02
- Title Cn
- 无乳糖牛奶和乳制品的健康影响——随机对照试验的系统评价
- Title En
- Health effects of lactose-free milk and dairy products – a systematic review of randomised controlled trials
- Bilingual Status
- complete