Meta AnalysisID 2982
1~5岁儿童乳糖不耐受的患病率、病因和诊断：1995-2015年文献的系统评价
CRD42015027202
What is the prevalence of primary and secondary lactose intolerance among children 1-5 years of age in different countries and populations around the world? Is there any specific age of onset of primary lactose intoleran
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Record Fields
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- Meta Analysis Id
- 2982
- Evidence Id
- 11540
- Core Evidence Id
- 11540
- Source Meta Analysis Id
- 2932
- Herb2 Meta Analysis Id
- HBMA002932
- Crd Id
- CRD42015027202
- Title
- Prevalence, cause and diagnosis of lactose intolerance in children aged 1-5 years: a systematic review of 1995-2015 literature
- Review Question
- What is the prevalence of primary and secondary lactose intolerance among children 1-5 years of age in different countries and populations around the world? Is there any specific age of onset of primary lactose intolerance in specific populations? What are the causes for secondary lactose intolerance in children 1-5 years? How is the diagnosis of primary or secondary lactose intolerance established?
- Study Type Included
- We will include randomized trials, observational and retrospective studies using the following inclusion and exclusion criteria. Inclusion criteria: 1. Specifically addresses lactose intolerance (infants/children 1-5 years of age, genetic risk, prevalence / incidence, timing of diagnosis, method of diagnosis, effects and symptoms, relationship to dietary patterns) 2. Focus on consumption of cow’s milk and related issues including CPMA and GI symptoms 3. Mentions transient or secondary lactose intolerance 4. Refers to lactose intolerance may be or is likely to be as a cause or component of another “plausible” disease/disorder/symptom (e.g. colic, gastrointestinal infections) Exclusion criteria: 1. Age range outside of research questions (for title/abstract screening, must be 0-5 years (if age range 4 - >5, exclude), and not preterm) 2. Specifically addresses or implies lactose intolerance but focused on treatment/management (including pre/pro-biotics and guidelines for feeding) 3. Specifically addresses lactose intolerance but focused on “implausible” relationship to other diseases (e.g. hypothyroidism) 4. Does not appear to address lactose intolerance in any manner (e.g. may be focused on unrelated/general food allergies, intolerances, sensitivities, or other identified issues with milk/milk abstinence etc.) 5. Pre-clinical/animal study, does not involve humans 6. Case study/ies 7. Primary focus is on another disease (eg autoimmune diseases, etc.) 8. Publication is not in English 9. Not a peer-reviewed publication 10. Replication/duplication of previous publication
- Condition Being Studied
- Participant
- Animal
- Human Disease Modelled
- Intervention
- We are not assessing an intervention in this systematic review. Instead, we are assessing the health outcomes associated with primary and secondary lactose intolerance.
- Comparator Control
- We are not assessing comparators(s) vs controls in this systematic review. Instead, we are assessing the health outcomes associated with primary and secondary lactose intolerance.
- Main Outcome
- Outcome Measure
- Additional Outcome
- Study Method
- Keyword
- Child; Humans; Lactose Intolerance; Prevalence; Publications
- Contact
- Organisational Affiliation
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Netherlands, Singapore
- Review Stage
- First Submission Date
- Registration Date
- 2015-10-15
- Anticipated Start Date
- Anticipated Completion Date
- Title Cn
- 1~5岁儿童乳糖不耐受的患病率、病因和诊断：1995-2015年文献的系统评价
- Title En
- Prevalence, cause and diagnosis of lactose intolerance in children aged 1-5 years: a systematic review of 1995-2015 literature
- Bilingual Status
- complete