Meta AnalysisID 2981
无乳糖配方对儿童急性腹泻治疗效果的影响：Meta分析
CRD42013003896
To compare the clinical outcomes of lactose-free formula with lactose containing formula for treatment of children suffering from acute diarrhea.
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Record Fields
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- Meta Analysis Id
- 2981
- Evidence Id
- 11539
- Core Evidence Id
- 11539
- Source Meta Analysis Id
- 2931
- Herb2 Meta Analysis Id
- HBMA002931
- Crd Id
- CRD42013003896
- Title
- Effects of lactose-free formula on the treatment of acute diarrhea in children:a meta-analysis
- Review Question
- To compare the clinical outcomes of lactose-free formula with lactose containing formula for treatment of children suffering from acute diarrhea.
- Study Type Included
- The history of antibiotic therapy is excluded. Children who had major systemic infections,severe malnutrition,shock or who suffer from an underlying disease that needs other special treatment were excluded.
- Condition Being Studied
- Diarrhea is defined by WHO as having three or more loose or liquid stools per day, or as having more stools than is normal for that person. Diarrhoea is one of the leading causes of death among children under five globally. It is recognized that people with diarrhoea may occur lack lactase, especially in Asia. But there is currently no appropriate consensus on the use of milk containing lactose or lactose-free.
- Participant
- The type of studies will be randomized controlled trials.The type of participants are children younger than three years old who have acute diarrhoea, either inpatients or outpatients.Acute diarrhoea is defined as having three or mo loose or liquid stools per day,or as having more stools than is normal. The duration of diarrhea should be less than two weeks.Trials that were studied patients who had bloody stools are excluded.
- Animal
- Human Disease Modelled
- Intervention
- The intervention group should use milk products with less than 2% lactose.It would be accepted that both group used fluid infusion, corrected electrolyte imbalance and acid-base disturbance and(or) received probiotics, mucosal protective agents.
- Comparator Control
- The control group should use milk products containing at least 2% lactose and the children who were previously breast-fed should suspend breast milk.
- Main Outcome
- Treatment failure rates and duration of diarrhea. Measures of effect Treatment failure is defined as worsening property of stools or clinical symptoms(rehydration, vomiting) and(or) stool amounts exceeding three times per day, or outpatients had to be hospitalized. Duration of diarrhoea is defined as time to improvement of diarrhoea.
- Outcome Measure
- Additional Outcome
- Weight gain. Measures of effect Weight gain referred to the weight change from admission to the end of the study.
- Study Method
- Intervention, Meta-analysis
- Keyword
- Acute Disease; Child; Diarrhea; Lactose; Humans
- Contact
- Wang Lin [email protected]
- Organisational Affiliation
- Children's hospital of Fudan University http://ch.shmu.edu.cn/eng.asp
- Funding Source
- Constuction of Key Clinical Specialty of Ministry of Health.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English, Chinese-Simplified
- Country
- China
- Review Stage
- Review Completed not published
- First Submission Date
- Registration Date
- 2013-03-04
- Anticipated Start Date
- 2013-01-06
- Anticipated Completion Date
- 2013-03-30
- Title Cn
- 无乳糖配方对儿童急性腹泻治疗效果的影响：Meta分析
- Title En
- Effects of lactose-free formula on the treatment of acute diarrhea in children:a meta-analysis
- Bilingual Status
- complete