Meta AnalysisID 2980
色氨酸水平及其代谢物在产后情绪低落和产后抑郁症发病机制中的作用：Meta分析与系统评价
CRD42021252462
How do serum tryptophan levels (and its metabolites) relate to postpartum psychiatric illness (in particular, postpartum blues and postpartum depression)?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2980
- Evidence Id
- 11538
- Core Evidence Id
- 11538
- Source Meta Analysis Id
- 2930
- Herb2 Meta Analysis Id
- HBMA002930
- Crd Id
- CRD42021252462
- Title
- Tryptophan levels and its metabolites in the pathogenesis of postpartum blues and postpartum depression: a meta-analysis and systematic review
- Review Question
- How do serum tryptophan levels (and its metabolites) relate to postpartum psychiatric illness (in particular, postpartum blues and postpartum depression)?
- Study Type Included
- Designs eligible for inclusion include: cross-sectional, cohort studies and prospective case-control studies. Only human studies will be included.
- Condition Being Studied
- Peripartum period, pregnancy Postpartum depression / postpartum blues, maternal mental health Serum tryptophan, serum kynurenine, tryptophan metabolites
- Participant
- Adult women (18 years and over) who are pregnant and/or in the postpartum period (defined as the first year after delivery). We will exclude women with a pre-existing psychiatric illness (excluding Major Depressive Disorder) and those who are using psychiatric medications or medications known to affect tryptophan levels.
- Animal
- Human Disease Modelled
- Intervention
- Serum tryptophan levels (and kynurenine and other tryptophan metabolites) A change in serum levels will be measured either as: 1) A difference between antepartum and postpartum levels at 1 week, 1 month, or greater than 1 month 2) A comparison of serum levels in the postpartum period (at 1 week, 1 month or greater than 1 month) to a matched control group of non-depressed postpartum women
- Comparator Control
- Not applicable
- Main Outcome
- Postpartum depression (defined as the onset of major depressive order, as per the DSM-V criteria, within the first 6 months postpartum) We will include studies that assess postpartum depression using symptoms questionnaires, screening measures or diagnostic assessments. Measures of effect
- Outcome Measure
- Additional Outcome
- Postpartum blues. Defined as feelings of sadness or moodiness with onset in the postpartum, but not meeting the criteria for major depressive disorder as per DSM-V. Diagnosed in studies using questionnaires, screening measures or diagnostic assessments.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Depression, Postpartum; Female; Humans; Postpartum Period; Risk Factors; Surveys and Questionnaires; Tryptophan
- Contact
- Amy Sylivris [email protected]
- Organisational Affiliation
- Monash University and Monash Health https://www.monash.edu/medicine/scs/psychiatry
- Funding Source
- Not applicable
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Australia
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-05-18
- Registration Date
- 2021-06-18
- Anticipated Start Date
- 2021-05-03
- Anticipated Completion Date
- 2021-12-01
- Title Cn
- 色氨酸水平及其代谢物在产后情绪低落和产后抑郁症发病机制中的作用：Meta分析与系统评价
- Title En
- Tryptophan levels and its metabolites in the pathogenesis of postpartum blues and postpartum depression: a meta-analysis and systematic review
- Bilingual Status
- complete