Meta AnalysisID 2960
口服异山梨酯治疗青光眼有效性与安全性的系统评价
CRD42022301625
To evaluate the effectiveness and safety of oral isosorbide in the treatment of glaucoma
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Record Fields
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- Meta Analysis Id
- 2960
- Evidence Id
- 11518
- Core Evidence Id
- 11518
- Source Meta Analysis Id
- 2909
- Herb2 Meta Analysis Id
- HBMA002909
- Crd Id
- CRD42022301625
- Title
- A systematic review of the effectiveness and safety of oral isosorbide in the treatment of glaucoma
- Review Question
- To evaluate the effectiveness and safety of oral isosorbide in the treatment of glaucoma
- Study Type Included
- Randomized controlled trials, non-randomized controlled trials, cohort studies, case series or case report studies
- Condition Being Studied
- Glaucoma is a group of ophthalmological diseases with characteristic optic nerve damage and visual field defects. It may damage the optic nerve and its visual pathways, and ultimately lead to visual impairment and even blindness. At present, glaucoma is the world's first non-blind eye disease, with a prevalence of 3.5% among people over 40; it is estimated that by 2040, there will be 110 million patients worldwide. At present, domestic and foreign guidelines recommend a combination of laser, surgery and drugs for treatment according to the patient's condition. Hypertonic dehydrating agents can reduce intraocular pressure by increasing plasma osmotic pressure to reduce intraocular pressure. They are mostly used in the treatment of acute attacks of primary glaucoma or secondary glaucoma. As a hypertonic dehydrating agent, isosorbide is widely used to reduce intracranial pressure. At present, there is a lack of large-scale randomized controlled clinical studies of isosorbide for reducing intraocular pressure in patients with glaucoma, and there is no basis for clinical application.
- Participant
- Glaucoma patients
- Animal
- Human Disease Modelled
- Intervention
- Single or continuous oral isosorbide
- Comparator Control
- Placebo or other penetrant
- Main Outcome
- Effectiveness: improvement rate of intraocular pressure and visual acuity. Safety: incidence of adverse reactions.
- Outcome Measure
- Additional Outcome
- Study Method
- Systematic review
- Keyword
- Glaucoma; Humans; Isosorbide Dinitrate
- Contact
- Shuo Feng [email protected]
- Organisational Affiliation
- Beijing Tongren Hospital, Capital Medical University
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-01-05
- Registration Date
- 2022-02-04
- Anticipated Start Date
- 2021-03-01
- Anticipated Completion Date
- 2022-03-01
- Title Cn
- 口服异山梨酯治疗青光眼有效性与安全性的系统评价
- Title En
- A systematic review of the effectiveness and safety of oral isosorbide in the treatment of glaucoma
- Bilingual Status
- complete