Meta AnalysisID 2956
β受体阻滞剂单用或联用单硝酸异山梨酯用于成人肝硬化食管胃静脉曲张出血的二级预防[Cochrane方案]
CRD42016045587
To assess the beneficial and harmful effects of beta-blockers alone or with isosorbide mononitrate versus placebo or no intervention for adults with cirrhosis and gastro-oesophageal varices that have bled.
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2956
- Evidence Id
- 11514
- Core Evidence Id
- 11514
- Source Meta Analysis Id
- 2905
- Herb2 Meta Analysis Id
- HBMA002905
- Crd Id
- CRD42016045587
- Title
- Beta-blockers alone or in combination with isosorbide mononitrate for secondary prevention of bleeding from gastro-esophageal varices in adults with cirrhosis and gastro-oesophageal varices [Cochrane Protocol]
- Review Question
- To assess the beneficial and harmful effects of beta-blockers alone or with isosorbide mononitrate versus placebo or no intervention for adults with cirrhosis and gastro-oesophageal varices that have bled.
- Study Type Included
- We will include randomised trials irrespective of blinding, language, year of publication, or publication status. In addition, we will include quasi-randomised trials and observational studies on our assessment of serious adverse events (Higgins 2011a).
- Condition Being Studied
- The Cochrane Hepato-Biliary Group
- Participant
- We will include people with cirrhosis and endoscopically verified gastro-oesophageal varices that have bled (secondary prevention), irrespective of the size of the varices (small or large varices) or the hepatic venous pressure gradient.
- Animal
- Human Disease Modelled
- Intervention
- We will include the following comparisons. Beta-blockers versus placebo or no intervention. Beta-blockers in combination of isosorbide mononitrate versus placebo or no intervention.</ul> We will include trials regardless of the dose of the interventions or treatment duration. We will exclude trials on carvedilol (a beta-blocker with alpha-blocking properties), as it is included in another review (Hobolth 2015). We will only allow co-interventions such as endoscopic therapy (e.g., banding ligation) if administered equally to the intervention and control group.
- Comparator Control
- We will include the following comparisons: Beta-blockers versus placebo or no intervention. Beta-blockers in combination of isosorbide mononitrate versus placebo or no intervention.
- Main Outcome
- All-cause mortality. Upper gastrointestinal bleeding of any cause. Serious adverse events defined as any untoward medical occurrence that does not necessarily have a causal relationship with the treatment (ICH GCP 1997). We will define serious adverse events as those that lead to death, were life threatening, or required hospitalisation or prolongation of hospitalisation (ICH GCP 1997). We will analyse adverse events separately (Loke 2011), and as a composite outcome (Gluud 2015). </ul>
- Outcome Measure
- Additional Outcome
- Bleeding from oesophageal varices. Bleeding-related mortality. Quality of life. Non-serious adverse events defined as all adverse events that do not fulfil the criteria for serious adverse events. Portal venous pressure expressed as the hepatic venous pressure gradient. </ul>
- Study Method
- Intervention, Systematic review
- Keyword
- Adrenergic beta-Antagonists; Adult; Drug Therapy; Drug Therapy, Combination; Esophageal and Gastric Varices; Hemorrhage; Humans; Isosorbide; Liver Cirrhosis; Secondary Prevention; Treatment Outcome
- Contact
- Lise Lotte Gluud [email protected]
- Organisational Affiliation
- The Cochrane Collaboration http://www.cochrane.org/
- Funding Source
- None, None
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Denmark
- Review Stage
- Review Ongoing
- First Submission Date
- Registration Date
- 2016-08-09
- Anticipated Start Date
- 2016-03-15
- Anticipated Completion Date
- 2017-04-29
- Title Cn
- β受体阻滞剂单用或联用单硝酸异山梨酯用于成人肝硬化食管胃静脉曲张出血的二级预防[Cochrane方案]
- Title En
- Beta-blockers alone or in combination with isosorbide mononitrate for secondary prevention of bleeding from gastro-esophageal varices in adults with cirrhosis and gastro-oesophageal varices [Cochrane Protocol]
- Bilingual Status
- complete