Meta AnalysisID 2951
乳三肽异亮氨酸-脯氨酸-脯氨酸和缬氨酸-脯氨酸-脯氨酸对亚洲人群血压的影响：随机对照试验的系统评价与Meta分析（更新）
CRD42014014322
Do the lactotripeptides Isoleucine–Proline–Proline and Valine–Proline–Proline reduce systolic blood pressure in Asian subjects ? What is the influence of the ingested dose of the lactotripeptides Isoleucine–Proline–Proli
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Record Fields
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- Meta Analysis Id
- 2951
- Evidence Id
- 11509
- Core Evidence Id
- 11509
- Source Meta Analysis Id
- 2901
- Herb2 Meta Analysis Id
- HBMA002901
- Crd Id
- CRD42014014322
- Title
- Influence of the lactotripeptides Isoleucine-Proline-Proline and Valine-Proline-Proline on blood pressure in Asian subjects: a systematic review and meta-analysis of randomized controlled trials (update)<br />
- Review Question
- Do the lactotripeptides Isoleucine–Proline–Proline and Valine–Proline–Proline reduce systolic blood pressure in Asian subjects ? What is the influence of the ingested dose of the lactotripeptides Isoleucine–Proline–Proline and Valine–Proline–Proline on the effect on blood pressure?
- Study Type Included
- Inclusion criteria: randomized controlled trials, single blinded or double blinded, involving the consumption of Isoleucine–Proline–Proline (IPP) and Valine–Proline–Proline (VPP) by Asian adult subjects for longer than 8 days, with office systolic blood pressure measurements at baseline and one/more time points.Exclusion criteria: reviews (general or systematic reviews, meta-analyses), letters, opinion papers, view points, etc…, non-human studies, studies which are not intervention trials, intervention trials which are not randomized-controlled trials, randomized-controlled trials with an open design, studies in which no measure of SBP was reported, studies in which there was no intervention with IPP+VPP (studies testing IPP alone or VPP alone will be excluded), studies where IPP/VPP intake period is less than 8 days
- Condition Being Studied
- Hypertension is a major determinant of health and is likely to have an effect on medical economics worldwide, including in Japan (Nakamura et al 2014). Hypertension can be prevented with lifestyle measures, such as physical activity, maintaining a normal body weight, and adopting a healthy diet. Besides this, several randomized trials and meta-analyses have shown that some peptides derived from milk proteins, such as isoleucine–proline–proline (IPP) and valine–proline–proline (VPP), decrease systolic blood pressure (SBP). However, the size of the effect varies among studies, and it seems to be stronger in Asian subjects than in European subjects (Cicero et al 2011). Several randomized trials have been performed in Japanese subjects. No sufficient meta-analysis has been performed to specifically assess the size of the effect in Asian subjects, especially in Japanese subjects, because many studies have been written in Japanese language and because the literature has not been searched for publications in Japanese language.
- Participant
- Inclusion: Asian adults (subjects older than 20 yo). Exclusion: studies in diseased subjects, studies in hypertensive patients receiving blood pressure lowering drugs, studies in children (younger than 20 yo)
- Animal
- Human Disease Modelled
- Intervention
- Intervention to be reviewed will be consumption of the lactotripeptides Isoleucine–Proline–Proline (IPP) and Valine–Proline–Proline (VPP) during more than 8 days
- Comparator Control
- Comparison will be made with placebo
- Main Outcome
- Change from baseline to endpoint in systolic blood pressure.
- Outcome Measure
- Additional Outcome
- Change from baseline to endpoint in diastolic blood pressure.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Asian Continental Ancestry Group; Blood Pressure; Humans; Oligopeptides
- Contact
- Dr Chanson-Rolle [email protected]
- Organisational Affiliation
- Funding Source
- The review was initially sponsored by Calpis Co., Ltd. (11-10, 5-chome, Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252-0206, Japan). Since Calpis has been acquired by Asahi Group Holdings, Ltd, the review is now sponsored by Asahi Group Holdings, Ltd (23-1, Azumabashi, 1-chome, Sumida-ku, Tokyo 130-8602, Japan).
- Other Selection Criteria
- Final Publication
- http://journals.plos.org/plosone/article?id&#61;10.1371/journal.pone.0142235
- Same Topic Review
- This systematic review is an update of the systematic review which was published on the PROSPERO register under the following title “Influence of the lactotripeptides Isoleucine-Proline-Proline and Valine-Proline-Proline on blood pressure in Asian subjects: a systematic review and meta-analysis of randomized controlled trials” and under registration number CRD42014014322.
- Published Protocol
- Review Type
- Language
- English, Japanese
- Country
- France, Japan
- Review Stage
- Review Ongoing
- First Submission Date
- 2018-07-05
- Registration Date
- 2014-10-17
- Anticipated Start Date
- 2014-09-11
- Anticipated Completion Date
- 2018-08-31
- Title Cn
- 乳三肽异亮氨酸-脯氨酸-脯氨酸和缬氨酸-脯氨酸-脯氨酸对亚洲人群血压的影响：随机对照试验的系统评价与Meta分析（更新）
- Title En
- Influence of the lactotripeptides Isoleucine-Proline-Proline and Valine-Proline-Proline on blood pressure in Asian subjects: a systematic review and meta-analysis of randomized controlled trials (update)<br />
- Bilingual Status
- complete