Meta AnalysisID 2947
大豆食品和大豆异黄酮对绝经后妇女肥胖相关炎症标志物的影响：系统评价与Meta分析
CRD42020179232
1. Does soy and soy isoflavones intake affect inflammatory markers of obesity in postmenopausal women? 2. Does this effect is associated with equol production status?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2947
- Evidence Id
- 11505
- Core Evidence Id
- 11505
- Source Meta Analysis Id
- 2897
- Herb2 Meta Analysis Id
- HBMA002897
- Crd Id
- CRD42020179232
- Title
- Effect of soy food and soy isoflavones on inflammatory markers of obesity in postmenopausal women: systematic review and meta-analysis
- Review Question
- 1. Does soy and soy isoflavones intake affect inflammatory markers of obesity in postmenopausal women? 2. Does this effect is associated with equol production status?
- Study Type Included
- Randomized controlled trials and crossover trials will be eligible; studies we eligible only if they will be published as full-text articles in peer-reviewed scientific journals. No language restrictions will be applied
- Condition Being Studied
- Aging is associated with increased inflammation what can play in the progression of cardiovascular disease. Since soy contains fiber, polyunsaturated fat, and phytoestrogens, which are individually associated with lower levels of inflammatory markers our systematic review and meta-analysis aimed to explore whether soy, as well as soy isoflavones intake, affects inflammatory markers of obesity among postmenopausal women. Since evidence suggests that responsiveness to isoflavones may vary according to a person’s equol-synthesizing capacity there was also the question if this effect is associated with equol production status.
- Participant
- Inclusion: postmenopausal women with specified diagnosis criteria of postmenopausal state Exclusion: Menopausal hormone therapy users; women in menopausal transition; premenopausal women
- Animal
- Human Disease Modelled
- Intervention
- Dietary intervention will include soy food items, soy proteins or soy isoflavones, no limit to frequency, duration and dosage.
- Comparator Control
- Trials with control group included placebo or comparison arm or diet without soy product
- Main Outcome
- IL-1β, IL-6, tumor necrosis factor α (TNF α); CRP; leptin; resistin; monocyte chemoattractant protein (chemokine MCP-1), and adiponectin Measures of effect Changes in inflammation markers
- Outcome Measure
- Additional Outcome
- s-equol level Measures of effect s-equol level / status
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Female; Humans; Isoflavones; Obesity; Postmenopause; Soy Foods; Soybean Proteins
- Contact
- Joanna Bajerska [email protected]
- Organisational Affiliation
- Institution of Human Nutrition and Dietetics, Poznan University of Life Sciences/Department of Health Management, Tokai University, Japan/Institute for World Health Development, Mukogawa Women’s University, Nishinomiya, Hyogo, Japan
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Japan, Poland
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-04-15
- Registration Date
- 2020-07-05
- Anticipated Start Date
- 2020-05-01
- Anticipated Completion Date
- 2020-08-01
- Title Cn
- 大豆食品和大豆异黄酮对绝经后妇女肥胖相关炎症标志物的影响：系统评价与Meta分析
- Title En
- Effect of soy food and soy isoflavones on inflammatory markers of obesity in postmenopausal women: systematic review and meta-analysis
- Bilingual Status
- complete