Meta AnalysisID 2946
异黄酮对绝经前和绝经后妇女乳腺密度影响的随机对照试验：一项系统评价与Meta分析
CRD42020156195
The purpose of this meta-analysis was to assess the impact of isoflavone-rich foods or supplements on pre- and post-menopausal women's breast density which is a biomarker of breast cancer risk.(breast density has been us
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2946
- Evidence Id
- 11504
- Core Evidence Id
- 11504
- Source Meta Analysis Id
- 2896
- Herb2 Meta Analysis Id
- HBMA002896
- Crd Id
- CRD42020156195
- Title
- Randomized controlled trials on the effect of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis
- Review Question
- The purpose of this meta-analysis was to assess the impact of isoflavone-rich foods or supplements on pre- and post-menopausal women's breast density which is a biomarker of breast cancer risk.(breast density has been used to assess the effects of treatment on breast tissue, which is influenced by prolonged exogenous replacement of hormones.)
- Study Type Included
- Randomized controlled trial
- Condition Being Studied
- Soy has been a staple in the diet in South and East Asian countries for many years and has become popular in Western countries as a result of the suggested health benefits .The relationship between soy food intake and breast cancer has been rigorously investigated for more than 34 years.There are conflicting experimental data on the effects of isoflavones on breast cancer in vitro and vivo. Although there are currently no reliable biomarkers of breast cancer risk, mammographic density has consistently been one of the best independent biomarkers. Only a few studies have examined the relationship between soy and isoflavones consumption, either before of after cancer diagnosis, and breast cancer outcomes. The 2010 report of the University of East Anglia systematic analysis focused on the effect of soy and isoflavones intake on the breast density of women, where eitht articles reported on this association. The report concluded that there was limited but generally consistent evidence suggesting that the percent of breast density decreased nonsignificantly in the soy and placebo groups. Since the report was published, some additonal studies on this issue have become available.
- Participant
- pre- and post-menopausal women
- Animal
- Human Disease Modelled
- Intervention
- Foods or supplements rich in isoflavones over a period of at least six months
- Comparator Control
- Compatator is placebo
- Main Outcome
- Details of mean breast density change(absolute change or as change per year) and variance of that change(or end breast density and its varicance where change data were not available) were collected for each arm of each included study at the latest time point available. Measures of effect Our analysis included randomized controlled trials (RCTs) of foods or supplements rich in isoflavones over a period of at least six months compared with placebos.
- Outcome Measure
- Additional Outcome
- None Measures of effect None
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Breast Density; Female; Humans; Isoflavones; Menopause; Postmenopause; Randomized Controlled Trials as Topic
- Contact
- Hui Wang [email protected]
- Organisational Affiliation
- The University of South China http://www.usc.edu.cn/
- Funding Source
- The Research Foundation of Education Bureau of Hunan Province, China (Grant No.17C1401)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2019-10-27
- Registration Date
- 2020-04-28
- Anticipated Start Date
- 2019-08-30
- Anticipated Completion Date
- 2020-01-31
- Title Cn
- 异黄酮对绝经前和绝经后妇女乳腺密度影响的随机对照试验：一项系统评价与Meta分析
- Title En
- Randomized controlled trials on the effect of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis
- Bilingual Status
- complete