Meta AnalysisID 2844
菊粉型果聚糖对代谢综合征及相关疾病患者肠道微生物群、糖脂代谢和炎症标志物的影响：随机对照试验的系统评价和Meta分析
CRD42022379825
The type of disease is Metabolic Syndrome and Related Disorders; Intervention is inulin-type fructans（ITF）; Outcomes are effects on Gut Microbiota（eg.The relative abundance of gut microbiota、Intestinal Permeability etc.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2844
- Evidence Id
- 11402
- Core Evidence Id
- 11402
- Source Meta Analysis Id
- 2786
- Herb2 Meta Analysis Id
- HBMA002786
- Crd Id
- CRD42022379825
- Title
- The Effects of inulin-type fructans on Gut Microbiota, Glycolipid metabolism and Inflammatory Markers in Patients with metabolic syndrome and related disorders:A Systematic Review and Meta-Analysis of Randomised Controlled Trials
- Review Question
- The type of disease is Metabolic Syndrome and Related Disorders; Intervention is inulin-type fructans（ITF）; Outcomes are effects on Gut Microbiota（eg.The relative abundance of gut microbiota、Intestinal Permeability etc.）, Glycolipid metabolism（eg.FBG、FINS、HbA1c、HOMA-IR、QUICKI；TG、TC、LDL、HDL etc.） and Inflammatory Markers（eg.CRP、hsCRP、TNF-α、IL-6 etc.）; Study method is Randomised Controlled Trial.
- Study Type Included
- the study was a human RCT (either parallel or cross-over design), and contained adequate data extracted from RCTs including the mean changes of outcome Parameters with standard deviations (SDs) and related 95% confdence intervals (CIs) for the intervention and placebo groups.
- Condition Being Studied
- Metabolic syndrome (MetS) is a cluster of symptoms that include glucose intolerance, insulin resistance, central obesity, dyslipidemia, and hypertension.The China Nutrition and Health Surveillance (2015–2017) showed that the prevalence of MetS was 31.1% among adults ≥20 years.It is also recognized as a chronic proinflammatory and prothrombotic state.In recent years, increasing evidence has demonstrated that the gut microbiota play a critical role in the development of inflammation and metabolic disorders.
- Participant
- Metabolic Syndrome and Related Disorders
- Animal
- Human Disease Modelled
- Intervention
- inulin-type fructans (ITF)
- Comparator Control
- placebo
- Main Outcome
- 1、Gut Microbiota（The relative abundance of gut microbiota） 2、Glycaemic parameters（FBG、FINS、HbA1c、HOMA-IR、QUICKI） 3、lipid metabolism（TG、TC、LDL、HDL ） 4、Inflammatory Markers（CRP、hsCRP、TNF-α、IL-6 ） Measures of effect Outcomes measured at conclusion of the supplementation period.The effect size for interest variables will calculated and reported as the pooled standard mean difference (SMD) and the 95% confidence interval (CI).
- Outcome Measure
- Additional Outcome
- None. Measures of effect Not applicable.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- C-Reactive Protein; Fructans; Gastrointestinal Microbiome; Glycated Hemoglobin; Glycolipids; Humans; Inulin; Metabolic Syndrome; Permeability; Randomized Controlled Trials as Topic
- Contact
- song jimei [email protected]
- Organisational Affiliation
- Guangzhou University of Chinese Medicine
- Funding Source
- 81873190
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-11-29
- Registration Date
- 2022-12-10
- Anticipated Start Date
- 2022-11-30
- Anticipated Completion Date
- 2023-01-31
- Title Cn
- 菊粉型果聚糖对代谢综合征及相关疾病患者肠道微生物群、糖脂代谢和炎症标志物的影响：随机对照试验的系统评价和Meta分析
- Title En
- The Effects of inulin-type fructans on Gut Microbiota, Glycolipid metabolism and Inflammatory Markers in Patients with metabolic syndrome and related disorders:A Systematic Review and Meta-Analysis of Randomised Controlled Trials
- Bilingual Status
- complete