Meta AnalysisID 2842
菊粉型果聚糖和餐后胃肠激素反应：随机对照试验的系统评价
CRD42021273438
Does inulin-type fructans supplementation affect postprandial gastrointestinal hormone responses in humans?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2842
- Evidence Id
- 11400
- Core Evidence Id
- 11400
- Source Meta Analysis Id
- 2784
- Herb2 Meta Analysis Id
- HBMA002784
- Crd Id
- CRD42021273438
- Title
- Inulin-type fructans and postprandial gastrointestinal hormone responses: a systematic review of randomised controlled trials
- Review Question
- Does inulin-type fructans supplementation affect postprandial gastrointestinal hormone responses in humans?
- Study Type Included
- Human studies - Randomised controlled trials (RCTs)
- Condition Being Studied
- Gastrointestinal hormones are secreted as a sign of nutrients arrival and energy intake; they communicate directly or indirectly with the brain to alter food intake and reward via their widely spread receptors. Inulin, a water-soluble non-digestible carbohydrate, is fermented by the gut microflora eliciting beneficial effects on glycaemic control (Wang et al. 2019) and blood lipids profile (Liu et al. 2017) and has also shown benefits on weight management (Liber & Szajewska 2013). In this systematic review we are interested to investigate whether inulin-type fructans supplementation has any effects on postprandial gastrointestinal hormone responses.
- Participant
- Adults older than 18 years old, any health status.
- Animal
- Human Disease Modelled
- Intervention
- All randomised controlled trials examining the effects of inulin-type fructans supplementation in any form (as a supplement per se or incorporated into food products), irrespective of their degree of polymerisation chain length (e.g. oligofructose, inulin, fructans, fructooligosaccharides from chicory, artichoke, agave etc) and not in combination with any other bioactive components.
- Comparator Control
- Non-inulin control, placebo.
- Main Outcome
- The main outcome is postprandial gastrointestinal hormone responses associated with inulin-type fructans supplementation. The RCTs should include at least one gut hormone (glucagon-like peptide 1 (GLP-1), peptide YY (PYY), gastroinhibitory peptide (GIP), ghrelin, cholecystokinin (CCK), or other) measured postprandially in order to be eligible. Studies assessing only fasting concentrations of gut hormones will not be included.
- Outcome Measure
- Additional Outcome
- Secondary outcomes include subjective appetite ratings (e.g. VAS) and energy intake (described only for already included studies for the primary outcome).
- Study Method
- Narrative synthesis, Systematic review
- Keyword
- Fructans; Gastrointestinal Hormones; Humans; Inulin; Postprandial Period
- Contact
- Nikoleta Stamataki [email protected]
- Organisational Affiliation
- University of Manchester, Harokopio University of Athens
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- England, Greece
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-08-17
- Registration Date
- 2021-09-15
- Anticipated Start Date
- 2021-08-23
- Anticipated Completion Date
- 2022-01-31
- Title Cn
- 菊粉型果聚糖和餐后胃肠激素反应：随机对照试验的系统评价
- Title En
- Inulin-type fructans and postprandial gastrointestinal hormone responses: a systematic review of randomised controlled trials
- Bilingual Status
- complete