Meta AnalysisID 2835
菊粉补充剂对2型糖尿病患者胰岛素代谢的疗效：随机对照试验的系统评价和Meta分析
CRD42019138208
We will discuss whether inulin improves the condition of insulin metabolism among T2DM patients.
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Record Fields
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- Meta Analysis Id
- 2835
- Evidence Id
- 11393
- Core Evidence Id
- 11393
- Source Meta Analysis Id
- 2778
- Herb2 Meta Analysis Id
- HBMA002778
- Crd Id
- CRD42019138208
- Title
- Efficacy of inulin supplementation on insulin metabolism in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials
- Review Question
- We will discuss whether inulin improves the condition of insulin metabolism among T2DM patients.
- Study Type Included
- Only RCTs were included and cross-over double-blinded or triple-blinded RCTs also be included.
- Condition Being Studied
- Type 2 diabetes mellitus, as a noncommunicable disease, is the main public health challenge in the 21st century. And it also accounts for 90%-95% of cases with diabetes, is a chronic disorder characterized by impaired metabolism of glucose and lipids due to impaired insulin secretion (beta cell dysfunction) or action (insulin resistance)
- Participant
- We enrolled the patients who were diagnosed as type 2 diabetes, and patients in intervention group received inulin but not in control group. Also, studies involving pregnant patients or patients younger than 18 years old will be excluded.
- Animal
- Human Disease Modelled
- Intervention
- The inulin in the intervention group is our target. The form of inulin in the intervention group could be: chicory enriched, oligofructose-enriched or included in synbiotic bread. The content of inulin ranges from 1.08g to 30g.
- Comparator Control
- The control group did not apply inulin but with maltodextrin, inulin placebo or control food.
- Main Outcome
- If there will be the decreasing of insulin and the improvement of HbA1c and HOMA-IR, the inulin is beneficial for T2DM patients in insulin metabolisim. Measures of effect The duration of included trials were from 6 weeks to 12 weeks. SMD values close to 0 (P > 0.05) indicated no statistical significance. In contrast, SMD was considered statistically significant when it was away from 0 (P＜0.05).
- Outcome Measure
- Additional Outcome
- None Measures of effect Not applicable
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Diabetes Mellitus, Type 2; Humans; Insulins; Inulin; Nutrition Therapy; Randomized Controlled Trials as Topic
- Contact
- Huaidong Hu [email protected]
- Organisational Affiliation
- The Second Affiliated Hospital of Chongqing Medical University
- Funding Source
- The Natural Science Foundation of China (grant no. 81171560), the “Par-Eu Scholars Program” of Chongqing City and the National Science and Technology Major Project of China (grant no. 2012ZX10002007001)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2019-06-07
- Registration Date
- 2019-08-07
- Anticipated Start Date
- 2019-05-04
- Anticipated Completion Date
- 2019-07-06
- Title Cn
- 菊粉补充剂对2型糖尿病患者胰岛素代谢的疗效：随机对照试验的系统评价和Meta分析
- Title En
- Efficacy of inulin supplementation on insulin metabolism in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials
- Bilingual Status
- complete