Meta AnalysisID 2833
菊粉型果聚糖摄入对血脂谱和血糖水平的影响：随机对照试验的系统评价和Meta分析
CRD42016037824
The effect of dietary intake inulin-type fructans on human lipid profile and glucose level is the question to be addressed. Several studies have reported that inulin-type fructans (ITF) has an effect on improving blo
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Record Fields
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- Meta Analysis Id
- 2833
- Evidence Id
- 11391
- Core Evidence Id
- 11391
- Source Meta Analysis Id
- 2776
- Herb2 Meta Analysis Id
- HBMA002776
- Crd Id
- CRD42016037824
- Title
- Effect of inulin-type fructans intake on lipid profile and glucose level, a systematic review and meta-analysis of randomized controlled trials
- Review Question
- The effect of dietary intake inulin-type fructans on human lipid profile and glucose level is the question to be addressed. Several studies have reported that inulin-type fructans (ITF) has an effect on improving blood lipid and glucose homeostasis in clinical trials. The meta-analysis was performed to assess the effects of ITF on human associated with metabolic abnormalities including dyslipidaemia, overweight or obesity, and type-2 diabetes
- Study Type Included
- Inclusion criteria: Primary research of RCTs published in English, including crossover RCTs
- Condition Being Studied
- Over the past few years, growing evidences shown that the gut microbiota play a critical role in the development of inflammation and metabolic disorders such as obesity, insulin resistance and type-2 diabetes. It is firmly established that the gut microbiota differs between obese and lean individuals, both in composition and function, a difference that has also been found between diabetic and non-diabetic individuals. Hence, it is the basis for prebiotic concept by dietary means to modulate the gut microbiota with potential benefits for glucose homeostasis and lipid profile. Dietary prebiotic supplementation might represent a potential therapeutic strategy for the prevention and treatment of metabolic abnormalities widespread in modern society.
- Participant
- Inclusion criteria: Trials were involved human participants with age >18 years. Exclusion criteria: participants with infection disease conditions such as chronic hepatitis and inflammatory bowel disease.
- Animal
- Human Disease Modelled
- Intervention
- Inclusion criteria: intwevention group receive a dietary prebiotic intervention, ,and the prebiotic was restricted to ITF (inulin, oligofructose, FOS and their mixtures). Exclusion criteria: 1. Interventions with the administration of probiotics (beneficial live micro-organisms) or synbiotics (a combination of pre- and probiotics) and other plant-derived carbohydrates such as arabino-xylan and ß-glucan; 2. Interventions with interference of medication or other functional food
- Comparator Control
- Inclusion criteria: control group received placebo maltodextrin or no supplementation Exclusion criteria: control group received glucose or Xylitol
- Main Outcome
- plasma lipid profile (TC, LDL-c, HDL-c and TG), fasting glucose and insulin
- Outcome Measure
- Additional Outcome
- homeostasis model assessment of insulin resistance (HOMA-IR) and C-react protein (CRP)
- Study Method
- Keyword
- Fructans; Glucose; Hematologic Tests; Humans; Inulin; Lipids; Randomized Controlled Trials as Topic; Triglycerides
- Contact
- Ms Long [email protected]
- Organisational Affiliation
- Southern Medical University http://www.fimmu.com/index_com.html
- Funding Source
- National Natural Science Foundation of China (NSFC313220143)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- Registration Date
- 2016-04-15
- Anticipated Start Date
- 2016-02-01
- Anticipated Completion Date
- 2016-08-01
- Title Cn
- 菊粉型果聚糖摄入对血脂谱和血糖水平的影响：随机对照试验的系统评价和Meta分析
- Title En
- Effect of inulin-type fructans intake on lipid profile and glucose level, a systematic review and meta-analysis of randomized controlled trials
- Bilingual Status
- complete