Meta AnalysisID 2828
巨大戟醇甲基丁烯酸酯治疗面部或头皮光化性角化病的疗效和耐受性：系统评价和Meta分析
CRD42017067977
What is the efficacy of ingenol mebutate gel in face/scalp actinic keratosis, compared to placebo or other treatment? What is the tolerability of ingenol mebutate gel in face/scalp actinic keratosis compared to other tre
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2828
- Evidence Id
- 11386
- Core Evidence Id
- 11386
- Source Meta Analysis Id
- 2771
- Herb2 Meta Analysis Id
- HBMA002771
- Crd Id
- CRD42017067977
- Title
- Efficacy and tolerability of ingenol mebutate in actinic keratosis of the face or scalp: systematic review and meta-analysis
- Review Question
- What is the efficacy of ingenol mebutate gel in face/scalp actinic keratosis, compared to placebo or other treatment? What is the tolerability of ingenol mebutate gel in face/scalp actinic keratosis compared to other treatment?
- Study Type Included
- We will include human clinical trials. We will not include case reports and case series studies.
- Condition Being Studied
- Actinic keratosis is a sun-related skin condition and is one of the most common reason for consulting a dermatologist. It is a premalignant skin condition which can develop into squamous cell carcinoma.
- Participant
- Inclusion criteria: Adults (18 years of age and above), 4-8 clinically typical, visible,discrete Aks within a contiguous 25cm2 treatment area on the face or scalp. Exclusion criteria: Target treatment area within 5cm of an incompletely healed wound, or within 10cm of a suspected basal cell or squammous cell carcinoma, presence of atypical lesions, recent use of medication or other procedures that could interfere with the evaluation of the treated area (e.g. topical medication, immunosuppresive agents, etc.).
- Animal
- Human Disease Modelled
- Intervention
- We will include clinical studies which have evaluated ingenol mebutate gel vs placebo or other therapies, for the treatment of actinic keratosis.
- Comparator Control
- Placebo/vehicle intervention or treatment other than ingenol mebutate (e.g. photodynamic therapy).
- Main Outcome
- Rate of complete clearance (CC).
- Outcome Measure
- Additional Outcome
- Severity of local skin reactions (LSR).
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Diterpenes; Face; Humans; Keratosis, Actinic; Scalp; Treatment Outcome
- Contact
- Andrea Vasas [email protected]
- Organisational Affiliation
- Faculty of Pharmacy, University of Szeged, Szeged, Hungary Medical School, University of Pécs, Pécs, Hungary http://aok.pte.hu/en; http://www.pharm.u-szeged.hu/english
- Funding Source
- Medical School, University of Pécs, Hungary PTE-AOK-KA-2017
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Hungary
- Review Stage
- Review Ongoing
- First Submission Date
- Registration Date
- 2017-05-26
- Anticipated Start Date
- 2017-02-20
- Anticipated Completion Date
- 2017-08-31
- Title Cn
- 巨大戟醇甲基丁烯酸酯治疗面部或头皮光化性角化病的疗效和耐受性：系统评价和Meta分析
- Title En
- Efficacy and tolerability of ingenol mebutate in actinic keratosis of the face or scalp: systematic review and meta-analysis
- Bilingual Status
- complete