Meta AnalysisID 2827
布洛芬、对乙酰氨基酚或吲哚美辛治疗动脉导管未闭的Meta分析的系统文献综述
CRD42020165457
This study is a systematic review of meta-analyses and network meta-analyses of the safety and efficacy of ibuprofen, paracetamol/acetaminophen, or indomethacin for the treatment of PDA in preterm and low birth weight in
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2827
- Evidence Id
- 11385
- Core Evidence Id
- 11385
- Source Meta Analysis Id
- 2770
- Herb2 Meta Analysis Id
- HBMA002770
- Crd Id
- CRD42020165457
- Title
- A systematic literature review of meta-analyses for the treatment of patent ductus arteriosus (PDA) with ibuprofen, paracetamol/acetaminophen, or indomethacin
- Review Question
- This study is a systematic review of meta-analyses and network meta-analyses of the safety and efficacy of ibuprofen, paracetamol/acetaminophen, or indomethacin for the treatment of PDA in preterm and low birth weight infants
- Study Type Included
- Meta-analyses and network meta-analyses of PDA treatment in randomzied controlled trials and observational studies.
- Condition Being Studied
- Patency of ductus arteriosus is essential during pregnancy for fetal survival. In relation to newborns, the ductus closes after delivery within the first three days of life. While with preterm infants, the closure may delay, resulting in several complications such as hemodynamically significant left to right shunt, prolongation of ventilatory support need, increased risk of congestive cardiac failure, intraventricular hemorrhage (IVH), pulmonary edema, bronchopulmonary dysplasia, renal failure, necrotizing enterocolitis (NEC), feeding intolerance, and reduced overall survival rate. PDA is defined as failure of ductus arteriosus to close within 72 hours of life. PDA is one of the most common cardiac disorders among premature infants, especially those under 28 weeks old of gestational age (GA)
- Participant
- any neonates diagnosed with PDA treated with ibuprofen, paracetamol/acetaminophen, or indomethacin
- Animal
- Human Disease Modelled
- Intervention
- ibuprofen, paracetamol/acetaminophen, or indomethacin
- Comparator Control
- ibuprofen, paracetamol/acetaminophen, indomethacin, placebo, control, no treatment
- Main Outcome
- Primary: if there are evidence that Ibuprofen, indomethacin and paracetamol/acetaminophen are more effective than placebo/no treatment for closure of PDA in terms of PDA closure Secondary: if there are evidence that Ibuprofen, indomethacin and paracetamol/acetaminophen are more effective than placebo/no treatment for closure of PDA in terms of risk of neonatal mortality, oliguria, intestinal perforation, bronchopulmonary dysplasia, intraventricular haemorrhage, necrotizing enterocolitis, gastrointestinal bleeding or stools positive for occult blood, duration of ventilator support (days), serum/plasma levels of creatinine after treatment (µmol/L), and neurodevelopmental impairment Measures of effect none.
- Outcome Measure
- Additional Outcome
- none Measures of effect none.
- Study Method
- Systematic review
- Keyword
- Humans
- Contact
- Daoud Al-Badriyeh [email protected]
- Organisational Affiliation
- Qatar University http://www.qu.edu.qa/
- Funding Source
- This research will not receive any specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Qatar
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-01-14
- Registration Date
- 2020-04-28
- Anticipated Start Date
- 2020-02-01
- Anticipated Completion Date
- 2021-02-28
- Title Cn
- 布洛芬、对乙酰氨基酚或吲哚美辛治疗动脉导管未闭的Meta分析的系统文献综述
- Title En
- A systematic literature review of meta-analyses for the treatment of patent ductus arteriosus (PDA) with ibuprofen, paracetamol/acetaminophen, or indomethacin
- Bilingual Status
- complete