Meta AnalysisID 2821
直肠给予吲哚美辛预防中重度ERCP术后胰腺炎和死亡并应在术前使用：一项基于汇总亚组数据的Meta分析
CRD42016038397
The effect of rectal indomethacin in preventing the rate of post-ERCP pancreatitis.
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Record Fields
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- Meta Analysis Id
- 2821
- Evidence Id
- 11379
- Core Evidence Id
- 11379
- Source Meta Analysis Id
- 2765
- Herb2 Meta Analysis Id
- HBMA002765
- Crd Id
- CRD42016038397
- Title
- Rectal Indomethacin Prevents Moderate to Severe Post- ERCP Pancreatitis and Death and Should Be Used Before the Procedure: A Meta-Analysis of Aggregate Subgroup Data
- Review Question
- The effect of rectal indomethacin in preventing the rate of post-ERCP pancreatitis.
- Study Type Included
- Only RCTs were included. No studies were excluded based on the language of publication, quality of study, duration of follow-up, or country of origin.
- Condition Being Studied
- Post-ERCp pancreatitis
- Participant
- All adult patients undergoing ERCP.
- Animal
- Human Disease Modelled
- Intervention
- We required that patients in the included trial be randomized to rectal indomethacin or placebo prior to or immediately after ERCP.
- Comparator Control
- Placebo
- Main Outcome
- The outcome of interest was the incidence of post-ERCP pancreatitis in the 7-day period following ERCP. Measures of effect The main outcome of interest was the incidence of PEP within a 7-day period following the ERCP. Secondary outcomes were set to compare incidence of moderate to severe post-ERCP pancreatitis in the 7-day period following ERCP as well as death.
- Outcome Measure
- Additional Outcome
- Incidence of severe post-ERCP pancreatitis in the 7-day period following ERCP.Incidence of post-ERCP mortality in the 7-day period following ERCP. Measures of effect Subgroup analyses and analyses of aggregate subgroup data were planned beforehand according to different patient characteristics that included high-risk versus average-risk for PEP; sphincter of Oddi dyskinesia; those undergoing pancreatic, biliary, or precut sphincterotomy or prophylactic pancreatic stent placement; and according to differing doses and timing of administration of rectal indomethacin. The analysis was also planned for the rate of moderate to severe pancreatitis and death. We respected authors’ definition of high-risk and average- risk population as mentioned previously.
- Study Method
- Intervention, Systematic review
- Keyword
- Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopic Retrograde; Humans; Indomethacin; Pancreatitis; Precision Medicine
- Contact
- Dr Yaghoobi [email protected]
- Organisational Affiliation
- McMaster University mcmaster.ca
- Funding Source
- Other Selection Criteria
- Final Publication
- Yaghoobi M, Alzahrani MA, McNabb-Baltar J, Martel M, Barkun AN. Rectal Indomethacin Prevents Moderate to Severe Post-ERCP Pancreatitis and Death and Should Be Used Before the Procedure: A Meta-Analysis of Aggregate Subgroup Data. J Can Assoc Gastroenterol. 2018 Mar 27;1(2):67-75. doi: 10.1093/jcag/gwy006. PMID: 31294402; PMCID: PMC6487993. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487993/
- Same Topic Review
- Yaghoobi M, Rolland S, Waschke KA, McNabb-Baltar J, Martel M, Bijarchi R, Szego P, Barkun AN. Meta-analysis: rectal indomethacin for the prevention of post-ERCP pancreatitis. Aliment Pharmacol Ther 2013 Nov;38(9):995-1001
- Published Protocol
- Review Type
- Language
- English
- Country
- Canada
- Review Stage
- Review Completed not published
- First Submission Date
- 2020-03-31
- Registration Date
- 2016-04-27
- Anticipated Start Date
- 2016-04-01
- Anticipated Completion Date
- 2016-05-31
- Title Cn
- 直肠给予吲哚美辛预防中重度ERCP术后胰腺炎和死亡并应在术前使用：一项基于汇总亚组数据的Meta分析
- Title En
- Rectal Indomethacin Prevents Moderate to Severe Post- ERCP Pancreatitis and Death and Should Be Used Before the Procedure: A Meta-Analysis of Aggregate Subgroup Data
- Bilingual Status
- complete