Meta AnalysisID 2820
吲哚美辛控制重度颅脑损伤后继发性颅内高压 [Cochrane方案]
CRD42015027139
To determine the efficacy, and gather evidence on safety, of indomethacin for people with severe traumatic brain injury.
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Record Fields
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- Meta Analysis Id
- 2820
- Evidence Id
- 11378
- Core Evidence Id
- 11378
- Source Meta Analysis Id
- 2764
- Herb2 Meta Analysis Id
- HBMA002764
- Crd Id
- CRD42015027139
- Title
- Indomethacin in controlling intracranial hypertension secondary to severe traumatic brain injury [Cochrane Protocol]
- Review Question
- To determine the efficacy, and gather evidence on safety, of indomethacin for people with severe traumatic brain injury.
- Study Type Included
- Randomised controlled trials are eligible for inclusion in this review.
- Condition Being Studied
- The Cochrane Injuries Group
- Participant
- We will include adults ≥ 18 years old, presenting with severe brain trauma (defined as having an initial Glasgow Coma Scale (GCS) score of < 8), due to any cause, and associated with elevated intracranial pressure (> 20 mmHg) with no previous decompressive surgery despite other co-morbilities.
- Animal
- Human Disease Modelled
- Intervention
- We will assess indomethacin compared with any control group, making sure that the comparison allows the determination of the specific effects of indomethacin (that is, the use of indomethacin must be the only difference between the intervention and control study arms). The intervention can be given to participants for any length of time.
- Comparator Control
- We will assess indomethacin compared with any control group, making sure that the comparison allows the determination of the specific effects of indomethacin (that is, the use of indomethacin must be the only difference between the intervention and control study arms). The intervention can be given to participants for any length of time.
- Main Outcome
- <ol> Intracranial pressure (mmHg) (measured by an epidural, subdural or intraparenchymatous brain catheter with continuous monitoring). We will group intracranial pressure values measured at similar time points across studies. </ol>
- Outcome Measure
- Additional Outcome
- <ol> Mortality, measured at approximately one month after the start of therapy. Adverse effects considered as serious by either the patient or the clinician. Disability, measured by the Glasgow Outcome Scale (GOS) or any other measures of neurological functioning or disability, six months after the start of therapy. Differences in quality of life (measured with a validated scale, such as the 36-Item Short Form Health Survey (SF-36) or the Davidson Trauma Scale (DTS), six months after the start of therapy. </ol>
- Study Method
- Keyword
- Brain Injuries; Humans; Indomethacin; Intracranial Hypertension; Treatment Effectiveness
- Contact
- Fernando G Baccaro [email protected]
- Organisational Affiliation
- The Cochrane Collaboration http://www.cochrane.org/
- Funding Source
- None, Instituto de Efectividad Clínica y Sanitaria
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Argentina
- Review Stage
- Review Ongoing
- First Submission Date
- Registration Date
- 2015-10-14
- Anticipated Start Date
- 2015-05-15
- Anticipated Completion Date
- 2017-05-15
- Title Cn
- 吲哚美辛控制重度颅脑损伤后继发性颅内高压 [Cochrane方案]
- Title En
- Indomethacin in controlling intracranial hypertension secondary to severe traumatic brain injury [Cochrane Protocol]
- Bilingual Status
- complete