Meta AnalysisID 2819
静脉注射吲哚美辛、静脉注射布洛芬、口服布洛芬、口服对乙酰氨基酚与安慰剂治疗早产儿症状性动脉导管未闭的系统评价和网状Meta分析
CRD42015015797
Systematic review and network meta-analysis comparing indomethacin, ibuprofen, acetaminophen with placebo for treatment of Patent Ductus Arteriosus in preterm infants.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2819
- Evidence Id
- 11377
- Core Evidence Id
- 11377
- Source Meta Analysis Id
- 2763
- Herb2 Meta Analysis Id
- HBMA002763
- Crd Id
- CRD42015015797
- Title
- Systematic review and network meta-analysis of IV indomethacin versus IV Ibuprofen versus oral Ibuprofen versus oral acetaminophen versus placebo for treatment of symptomatic patent ductus arteriosus in preterm infants
- Review Question
- Systematic review and network meta-analysis comparing indomethacin, ibuprofen, acetaminophen with placebo for treatment of Patent Ductus Arteriosus in preterm infants.
- Study Type Included
- Randomized controlled trials
- Condition Being Studied
- Management of patent ductus arteriosus (PDA) in preterm infants is one of the most controversial topics in neonatal medicine. It is associated with a number of co-morbidities like necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD) and intraventricular hemorrhage (IVH). The management dilemmas have mainly centered on when to treat and with what to treat. To increase the complexity of matters, these two aspects of PDA management are not mutually exclusive, with the modality of treatment often being dictated by the timing of treatment. There have been a large number of published studies, meta-analyses, reviews, and editorials focusing on different aspects of management dilemmas. Regarding the timing of treatment, prophylactic therapy has gradually fallen out of favor and neonatal units have shifted towards a more conservative approach by treating only the clinically and echocardiographically significant PDAs. However, the big dilemma that still persists among neonatologists is what to use as the primary modality of treatment.
- Participant
- Preterm infants with hemodynamically significant PDA
- Animal
- Human Disease Modelled
- Intervention
- 1. Intravenous Indomethacin or 2. Intravenous Ibuprofen or 3. Oral Ibuprofen or 4. Oral Acetaminophen or 5. IV acetaminophen Inclusion criteria: trials included in our review will have 1) Indomethacin or Ibuprofen or Acetaminophen being used for the treatment of clinically and/or echocardiographically determined hemodynamically significant PDA ; 2) have randomized infants to two intervention arms using the above mentioned drugs or an intervention arm using one of the above mentioned drugs and a control arm. Exclusion criteria: use of any intervention for prophylaxis
- Comparator Control
- Any of the interventions or placebo
- Main Outcome
- Closure of PDA
- Outcome Measure
- Additional Outcome
- Incidence of necrotizing enterocolitis Incidence of oliguria Duration of ventilatory support
- Study Method
- Keyword
- Acetaminophen; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Newborn; Infant, Premature
- Contact
- Dr Mitra [email protected]
- Organisational Affiliation
- McMaster University
- Funding Source
- Other Selection Criteria
- Final Publication
- Mitra S, Florez ID, Tamayo ME, Mbuagbaw L, Vanniyasingam T, Veroniki AA, Zea AM, Zhang Y, Sadeghirad B, Thabane L. Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-analysis. JAMA. 2018 Mar 27;319(12):1221-1238. doi: 10.1001/jama.2018.1896. Review. PubMed PMID: 29584842; PubMed Central PMCID: PMC5885871. https://www.ncbi.nlm.nih.gov/PubMed/29584842
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- England, Canada, Colombia
- Review Stage
- Review Completed published
- First Submission Date
- 2018-08-02
- Registration Date
- 2015-06-30
- Anticipated Start Date
- 2015-07-01
- Anticipated Completion Date
- 2016-04-01
- Title Cn
- 静脉注射吲哚美辛、静脉注射布洛芬、口服布洛芬、口服对乙酰氨基酚与安慰剂治疗早产儿症状性动脉导管未闭的系统评价和网状Meta分析
- Title En
- Systematic review and network meta-analysis of IV indomethacin versus IV Ibuprofen versus oral Ibuprofen versus oral acetaminophen versus placebo for treatment of symptomatic patent ductus arteriosus in preterm infants
- Bilingual Status
- complete