Meta AnalysisID 2814
外用青黛制剂治疗银屑病：一项系统评价和Meta分析
CRD42022326526
The aim of this systematic review and meta analysis is to evaluate the efficacy and safety of topical indigo naturalis preparation for psoriasis.
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Record Fields
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- Meta Analysis Id
- 2814
- Evidence Id
- 11372
- Core Evidence Id
- 11372
- Source Meta Analysis Id
- 2758
- Herb2 Meta Analysis Id
- HBMA002758
- Crd Id
- CRD42022326526
- Title
- Topical indigo naturalis preparation in the treatment of psoriasis: a systematic review and meta-analysis
- Review Question
- The aim of this systematic review and meta analysis is to evaluate the efficacy and safety of topical indigo naturalis preparation for psoriasis.
- Study Type Included
- Randomized controlled trials (RCTs) concerning efficacy and safety of topical indigo naturalis preparation in the treatment of psoriasis will be included.
- Condition Being Studied
- Psoriasis is an inflammatory and relapsing skin disease that affects at least 1.25 billion people's physical and mental health all around the world. Nowadays, there is an increasing risk of psoriasis comorbidites such as psoriatic arthritis and cardiometabolic diseases, which has attached great importance to psoriasis treatment. At present, the treatment of psoriasis is mainly biologics and oral systematic therapies such as methotrexate, which are reported to increase adverse events in the longterm medication. In terms of the issue of adverse events occuring in the treatment of psoriasis, Chinese herbal medicine treatment may be an adjuvant treatment even effective alternative treatment for psoriasis.
- Participant
- All participants diagnosed with psoriasis will be concerned. There will be no restrictions on sex, age, race, economic status, or education.
- Animal
- Human Disease Modelled
- Intervention
- Any studies reporting topical indigo naturalis preparation treatment will be included. Topical indigo naturalis preparation could be used alone or combined with routine pharmacotherapy.
- Comparator Control
- The control interventions will include placebo, routine pharmacotherapy, other conventional treatments and no treatment.
- Main Outcome
- The primary outcome will be Psoriasis Area and Severity Index (PASI) score.
- Outcome Measure
- Additional Outcome
- The additional outcomes will be assessed as follows: (1) Clinical response rate measured by Psoriasis Area and Severity Index (PASI) score; (2) Dermatology Life Quality Index (DLQI) score; (3) Physician Global Assessment (PGA) score or Investigator Global Assessment (IGA) score; (4) Visual Analogue Scale (VAS) score; (5) Adverse event; (6) Relapse or recurrence.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Humans; Indigo Carmine; Indigofera; Phytotherapy; Psoriasis
- Contact
- Ziqing Li [email protected]
- Organisational Affiliation
- Guangzhou University of Chinese Medicine
- Funding Source
- This study will be supported by grants of Key-Area Research and Development Program of Guangdong Province (No. 2020B1111100005), Specific Clinical Research Project of Guangdong Provincial Hospital of Chinese Medicine (No. YN10101909), Research Fund for Bajian Talents of Guangdong Provincial Hospital of Chinese Medicine (No. BJ2022KY17), Guangdong Basic and Applied Basic Research Foundation (No. 2019A1515111094) and the 2020 Guangdong Provincial Science and Technology Innovation Strategy Special Fund (Guangdong-Hong Kong-Macau Joint Lab) (No. 2020B1212030006).
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-05-22
- Registration Date
- 2022-06-03
- Anticipated Start Date
- 2022-06-01
- Anticipated Completion Date
- 2023-06-01
- Title Cn
- 外用青黛制剂治疗银屑病：一项系统评价和Meta分析
- Title En
- Topical indigo naturalis preparation in the treatment of psoriasis: a systematic review and meta-analysis
- Bilingual Status
- complete