Meta AnalysisID 2813
青黛治疗溃疡性结肠炎的疗效与安全性的Meta分析
CRD42021279766
The purpose of the meta-analysis of this randomized controlled trial was to evaluate the efficacy and safety of the traditional Chinese medicine indigo naturalis on ulcerative colitis.
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Record Fields
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- Meta Analysis Id
- 2813
- Evidence Id
- 11371
- Core Evidence Id
- 11371
- Source Meta Analysis Id
- 2757
- Herb2 Meta Analysis Id
- HBMA002757
- Crd Id
- CRD42021279766
- Title
- Meta-analysis of efficacy and safety of indigo naturalis in the treatment of ulcerative colitis
- Review Question
- The purpose of the meta-analysis of this randomized controlled trial was to evaluate the efficacy and safety of the traditional Chinese medicine indigo naturalis on ulcerative colitis.
- Study Type Included
- Randomized controlled trials (RCTs) will be included.
- Condition Being Studied
- Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease involving the colon and rectum, and its etiology remains unknown. The lesions are confined to the mucosa and submucosa of the large intestine. Most of the lesions are located in the sigmoid colon and rectum, but they can also extend into the descending colon or even the entire colon. The duration of UC is usually prolonged. Its clinical manifestations include persistent or recurrent diarrhea, mucopurulent bloody stool with abdominal pain, and tenesmus, of which mucopurulent bloody stool is the most common symptom. In recent years, the incidence of UC has been increasing year by year worldwide, even in developing countries where the incidence was previously low.
- Participant
- (1) Study type: clinical randomized controlled trial, with or without blind method and no limitation in publication language; (2) Subjects: All patients who met the diagnostic criteria for ulcerative colitis. Diagnostic criteria: TCM diagnostic criteria were mainly determined by referring to Practical Internal Medicine and Criteria for Diagnosis and Therapeutic Effect of Diseases and Syndromes in TCM. Western medicine diagnostic criteria were mainly formulated with reference to Criteria for Diagnosis and Therapeutic Effect of Ulcerative Colitis. Patients' age, course of disease and source of cases are not limited; (3) Intervention measures: treatment group was treated with indigo naturalis; The control group was treated with western medicine. (4) Outcome measures: At least one of the following measures was adopted: ① Total effective rate; ② Efficacy evaluation under colonoscopy; ③ TCM symptom scores; ④ Score of intestinal mucosal lesion; ⑤ Sutherland disease activity index (DAI) and maintenance response rate; ⑥ Recurrence rate; ⑦ Adverse reactions.
- Animal
- Human Disease Modelled
- Intervention
- The main intervention measure of the experimental group was oral administration of Indigo Naturalis。
- Comparator Control
- The intervention method of the control group was oral administration of western medicine (mesalazine or sulfasalazine).
- Main Outcome
- Clinical response rate at 8 weeks of treatment.
- Outcome Measure
- Additional Outcome
- Clinical remission rate and mucosal healing rate after 8 weeks of treatment.
- Study Method
- Keyword
- Colitis, Ulcerative; Humans; Indigo Carmine; Indigofera; Psoriasis
- Contact
- Wei Wei [email protected]
- Organisational Affiliation
- Wangjing Hospital of China Academy of Chinese Medical Sciences
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-09-20
- Registration Date
- 2021-10-21
- Anticipated Start Date
- 2021-09-20
- Anticipated Completion Date
- 2021-11-20
- Title Cn
- 青黛治疗溃疡性结肠炎的疗效与安全性的Meta分析
- Title En
- Meta-analysis of efficacy and safety of indigo naturalis in the treatment of ulcerative colitis
- Bilingual Status
- complete