Meta AnalysisID 2810

甘油灌肠剂与栓剂在早产儿中的应用：一项系统评价与Meta分析

CRD42020198431

How does the use of glycerin suppositories or enemas in premature infants impact time to full enteral feeding compared to no treatment or placebo?

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Meta Analysis Id: 2810
Evidence Id: 11368
Core Evidence Id: 11368
Source Meta Analysis Id: 2755
Herb2 Meta Analysis Id: HBMA002755
Crd Id: CRD42020198431
Title: Glycerin Enemas and Suppositories in Premature Infants: A Systematic Review and Meta-analysis
Review Question: How does the use of glycerin suppositories or enemas in premature infants impact time to full enteral feeding compared to no treatment or placebo?
Study Type Included: We will assess randomized controlled trials to measure the effects of using glycerin suppositories or enemas in premature infants.
Condition Being Studied: Enteral feeding in premature infants.
Participant: Inclusion: premature infants (<32 weeks and/or birth weight of <1500 grams) Exclusion: infants >32 weeks of age or with major congenital and/or gastrointestinal anomalies present
Animal
Human Disease Modelled
Intervention: The intervention will consist of glycerin suppositories or enemas used either prophylactically or as rescue therapy for jaundice or feeding intolerance in premature infants. Delayed meconium passage is thought to be linked to delays in the transition to enteral feeding, so glycerin suppositories and enemas are often used to expedite this process. We will specifically be looking at the treatment type (suppository or enema) and the treatment duration.
Comparator Control: The control will be either placebo interventions or no treatment.
Main Outcome: The main outcomes will be mortality (defined as death of the patient), necrotizing enterocolitis (NEC) (defined as diagnosis of NEC using Bell staging), rectal perforation (defined as diagnosis of rectal perforation), rectal bleeding (defined as gross but not occult blood per rectum), jaundice (defined as yellowing of skin due to elevated bilirubin), transition to enteral feeding (defined as difference in number of days between mean or median start of enteral feeding and full enteral feeding), and meconium evacuation (defined as days until first meconium evacuation). Measures of effect Dichotomous outcomes will be reported as counts, frequency, and relative risk with 95% confidence intervals. Continuous data (e.g., days to full feeds) will be reported as mean, standard deviation, and mean differences with 95% confidence intervals.
Outcome Measure
Additional Outcome: None Measures of effect N/A
Study Method: Intervention, Meta-analysis, Systematic review
Keyword: Enema; Glycerol; Humans; Infant, Newborn; Infant, Premature; Suppositories
Contact: Raymond Lay [email protected]
Organisational Affiliation: University of Rochester Medical Center (URMC)
Funding Source
Other Selection Criteria
Final Publication
Same Topic Review: This review is an update of a previous systematic review and meta-analysis. This is being conducted due to the publication of new trials on this topic. Reference: Livingston, M.H., Shawyer, A.C., Rosenbaum, P.L., Williams, C., Jones, S.A., Walton, J.M. Glycerin Enemas and Suppositories in Premature Infants: A Meta-analysis. Pediatrics. 2015;135(6):1093-1106.
Published Protocol
Review Type
Language: English
Country: United States of America
Review Stage: Review Ongoing
First Submission Date: 2020-07-21
Registration Date: 2020-08-21
Anticipated Start Date: 2020-07-27
Anticipated Completion Date: 2020-11-02
Title Cn: 甘油灌肠剂与栓剂在早产儿中的应用：一项系统评价与Meta分析
Title En: Glycerin Enemas and Suppositories in Premature Infants: A Systematic Review and Meta-analysis
Bilingual Status: complete