Meta AnalysisID 2808
甘油与甘露醇用于脑水肿及颅内压增高患者的疗效与安全性比较：一项系统评价与Meta分析
CRD42020187691
we aimed to compare the efficacy and safety of glycerol versus mannitol for the treatment of cerebral edema and elevated intracranial pressure in this meta-analysis.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2808
- Evidence Id
- 11366
- Core Evidence Id
- 11366
- Source Meta Analysis Id
- 2753
- Herb2 Meta Analysis Id
- HBMA002753
- Crd Id
- CRD42020187691
- Title
- Comparative efficacy and safety of glycerol versus mannitol in patients with cerebral edema and elevated intracranial pressure: A systematic review and meta-analysis
- Review Question
- we aimed to compare the efficacy and safety of glycerol versus mannitol for the treatment of cerebral edema and elevated intracranial pressure in this meta-analysis.
- Study Type Included
- Controlled trials
- Condition Being Studied
- Cerebral edema and elevated intracranial pressure (ICP) are common neurologic complications in varieties of cerebral disorders, such as traumatic brain injury (TBI), ischemic stroke (IS), intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH), and infections. Moreover, they are often recognized as contributors to secondary brain injury, devastating neurological outcomes, and even causing brain death.
- Participant
- Human adults or animals with definite cerebral edema or elevated ICP, irrespective of the underlying pathology (TBI, IS, ICH, or else).
- Animal
- Human Disease Modelled
- Intervention
- Glycerol infusion: an osmotic agent; effectively relieve cerebral edema, reduce the ICP, and improve cerebral blood flow.
- Comparator Control
- Mannitol, a six-carbon nonmetabolizable osmotic agent, increases plasma osmolality to establish an osmotic gradient across the blood-brain barrier, promoting the movement of water from the cerebral into vascular space, reducing the cerebral volume and ICP.
- Main Outcome
- Primary efficacy outcomes were the control of cerebral edema and the change of ICP. Secondary efficacy outcomes were the improvement of neurological function, including the measurements of Neurological Severity Scores (NSS), Glasgow Coma Scale (GCS), recovery of memory function with latency values. Safety outcomes were drug-related adverse events, including acute kidney injury (AKI), elevated serum creatinine (SCr) level, elevated blood urea nitrogen (BUN) level, proteinuria, serum electrolyte disturbances; rebound events; hemolysis; and elevated blood glucose levels in the follow-up period. Measures of effect Relative risks; WMD/SMD
- Outcome Measure
- Additional Outcome
- None Measures of effect None
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Brain Edema; Diuretics, Osmotic; Glycerol; Humans; Intracranial Hypertension; Mannitol
- Contact
- Jia Wang [email protected]
- Organisational Affiliation
- Zhejiang University School of medicine, Sir Run Run Shaw Hospital,
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-05-21
- Registration Date
- 2020-07-05
- Anticipated Start Date
- 2020-05-01
- Anticipated Completion Date
- 2020-06-20
- Title Cn
- 甘油与甘露醇用于脑水肿及颅内压增高患者的疗效与安全性比较：一项系统评价与Meta分析
- Title En
- Comparative efficacy and safety of glycerol versus mannitol in patients with cerebral edema and elevated intracranial pressure: A systematic review and meta-analysis
- Bilingual Status
- complete