Meta AnalysisID 2802
伊波加因的不良反应：一项文献系统评价（2015-2020年）并特别关注药物相互作用
CRD42020201481
The aim of this manuscript is to perform a systematic review of literature in order to collect all the adverse events and fatalities associated with ibogaine. Those cases in which ibogaine was combined with other drugs w
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Record Fields
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- Meta Analysis Id
- 2802
- Evidence Id
- 11360
- Core Evidence Id
- 11360
- Source Meta Analysis Id
- 2747
- Herb2 Meta Analysis Id
- HBMA002747
- Crd Id
- CRD42020201481
- Title
- The adverse effects of ibogaine: A systematic review of literature (2015-2020) with special attention to drug-drug interactions
- Review Question
- The aim of this manuscript is to perform a systematic review of literature in order to collect all the adverse events and fatalities associated with ibogaine. Those cases in which ibogaine was combined with other drugs will receive special attention, since potential mechanisms of drug-drug interactions has been poorly described.
- Study Type Included
- All studies published in peer-reviewed journals involving the use of ibogaine in humans were included. These included case reports, clinical studies, observational studies, and letters. Books and book chapters indexed in the above-cited databases were also included.
- Condition Being Studied
- The aim of this manuscript is to perform a systematic review of literature in order to collect all the adverse events and fatalities associated with ibogaine. Those cases in which ibogaine was combined with other drugs will receive special attention, since potential mechanisms of drug-drug interactions has been poorly described. By this manner, thousands of patients using ibogaine in uncontrolled settings are currently exposed to potential interactions. Researchers interested in testing the safety/efficacy of ibogaine for the treatment of opiate dependence could also benefit from this information. We included all studies that described ibogaine use in humans and reported information regarding physical and adverse effects (including intoxications).
- Participant
- All subjects that used at least one dose of ibogaine were included.
- Animal
- Human Disease Modelled
- Intervention
- All designs evaluating the adverse effects of ibogaine, serious adverse events, fatalities, and drug-drug interactions between ibogaine and other drugs were included.
- Comparator Control
- All designs evaluating the adverse effects of ibogaine, serious adverse events, fatalities, and drug-drug interactions between ibogaine and other drugs were included.
- Main Outcome
- We included all reports that assessed adverse effects systematically (with standardized scales and/or physical and biological measures) or non-systematically (any subjective or physical effect described by the authors as adverse or negative), and reports of intoxications and deaths. Measures of effect We included all reports that assessed adverse effects systematically (with standardized scales and/or physical and biological measures) or non-systematically (any subjective or physical effect described by the authors as adverse or negative), and reports of intoxications and deaths.
- Outcome Measure
- Additional Outcome
- none Measures of effect We included all reports that assessed adverse effects systematically (with standardized scales and/or physical and biological measures) or non-systematically (any subjective or physical effect described by the authors as adverse or negative), and reports of intoxications and deaths.
- Study Method
- Intervention, Synthesis of qualitative studies, Systematic review
- Keyword
- Drug Interactions; Hallucinogens; Humans; Ibogaine; Substance-Related Disorders
- Contact
- Juliana Rocha [email protected]
- Organisational Affiliation
- USP
- Funding Source
- National Institute for Translational Medicine (INCT-TM), CNPq, Brazil. ICEERS Foundation (International Center for Ethnobotanical Education, Research and Services), Barcelona, Spain. Department of Neuroscience and Behavior, Ribeirão Preto Medical School, University of São Paulo, SP, Brazil. CNPQ- Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- We only selected studies published between 15-2020. Two reviews provided the known fatalities or adverse events related to Iboga/ibogaine use (Alper et al., 2012; Koenig & Hilber, 2015), while a third one analyzed the anti-addictive potential of ibogaine (dos Santos et al., 2016).
- Published Protocol
- Review Type
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-08-01
- Registration Date
- 2020-09-01
- Anticipated Start Date
- 2020-07-23
- Anticipated Completion Date
- 2020-12-01
- Title Cn
- 伊波加因的不良反应：一项文献系统评价（2015-2020年）并特别关注药物相互作用
- Title En
- The adverse effects of ibogaine: A systematic review of literature (2015-2020) with special attention to drug-drug interactions
- Bilingual Status
- complete