Meta AnalysisID 2795
汞、不孕症及受孕时间：一项系统评价与Meta分析
CRD42022346325
Is elevated mercury as measured by biomarkers associated with infertility or time-to-conception?
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Record Fields
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- Meta Analysis Id
- 2795
- Evidence Id
- 11353
- Core Evidence Id
- 11353
- Source Meta Analysis Id
- 2740
- Herb2 Meta Analysis Id
- HBMA002740
- Crd Id
- CRD42022346325
- Title
- Mercury, infertility and time-to-conception: a systematic review and meta-analysis
- Review Question
- Is elevated mercury as measured by biomarkers associated with infertility or time-to-conception?
- Study Type Included
- We will include cohort studies, cross-sectional studies and case-control studies. We do not expect any experimental studies will be relevant due to the harmful nature of the exposure of interest. Clinical reviews, systematic reviews, meta-analyses and case reports will be excluded.
- Condition Being Studied
- The association between mercury exposure and reproductive health outcomes
- Participant
- Inclusion: Adults (male or female) attempting to conceive naturally or through artificial reproductive technology. Exclusion: Adolescents attempting to conceive.
- Animal
- Human Disease Modelled
- Intervention
- The exposure of interest is mercury as assessed by measurement of biomarkers. Studies that assess mercury levels ascertained from individual blood, serum, plasma, hair, urine, fingernail or toenail samples will be included. Studies that estimate individual mercury exposure from the environment or through dietary questionnaires will be excluded.
- Comparator Control
- Individuals in the highest category of mercury exposure will be compared with individuals in the lowest category of mercury exposure. We anticipate that the precise cut-points will differ among the included studies.
- Main Outcome
- The primary outcomes of interest are time-to-conception (prospectively collected or retrospective recalled, infertility will be defined as > 12 months) and the in vitro fertilization outcomes of fertilization or clinical pregnancy. Studies will be excluded if they only report laboratory measures of reproductive characteristics such as hormone levels or semen characteristics. Measures of effect Studies must report risk ratios, odds ratios or hazard ratios and 95% confidence intervals or report enough information that these estimates can be calculated to be included.
- Outcome Measure
- Additional Outcome
- None.
- Study Method
- Epidemiologic, Meta-analysis, Systematic review
- Keyword
- Humans; Infertility; Mercury
- Contact
- Meghan Angley [email protected]
- Organisational Affiliation
- Department of Obstetrics and Gynecology, Columbia University Medical Center https://www.obgyn.columbia.edu
- Funding Source
- This study was partially supported by the grants awarded to Dr. Ka Kahe from the National Institutes of Health (see below). Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> National Institute of Diabetes and Digestive and Kidney Diseases Grant Number: R01DK116603, PI: Ka Kahe, Date: 2018 National Institute on Aging Grant Number: RF1AG056111, PI: Ka Kahe, Date: 2017
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-07-15
- Registration Date
- 2022-07-26
- Anticipated Start Date
- 2022-04-26
- Anticipated Completion Date
- 2022-10-01
- Title Cn
- 汞、不孕症及受孕时间：一项系统评价与Meta分析
- Title En
- Mercury, infertility and time-to-conception: a systematic review and meta-analysis
- Bilingual Status
- complete