Meta AnalysisID 2794
重金属汞与糖尿病的关联：一项系统评价与Meta分析
CRD42022322375
Is mercury exposure causing diabetes？
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2794
- Evidence Id
- 11352
- Core Evidence Id
- 11352
- Source Meta Analysis Id
- 2739
- Herb2 Meta Analysis Id
- HBMA002739
- Crd Id
- CRD42022322375
- Title
- Association between heavy metal mercury and diabetes mellitus: A systematic review and meta-analysis
- Review Question
- Is mercury exposure causing diabetes？
- Study Type Included
- Cohort studies, case-control studies and cross-sectional studies will be included.
- Condition Being Studied
- The prevalence of diabetes worldwide is still on the rise.The potential impact of environmental factors on the diabetes epidemic is receiving increasing attention. It is well known that the Minamata disease outbreak in Japan in 1956 was caused by high levels of mercury exposure. Exposure to high levels of mercury can cause changes in the central nervous system, in addition to affecting a variety of human organs, including cardiovascular, renal, endocrine, reproductive and immune systems. Some studies support a link between mercury exposure and diabetes. But there have been reports of conflicting conclusions. Therefore, this meta-analysis aims to explore the relationship between mercury exposure and the development of diabetes.
- Participant
- The population in the retrieved literature used to investigate mercury and diabetes mellitus will be the subject of review, unless the literature is of low quality, lacks baseline information, the observation endpoint is not diabetes, or the data is inappropriate.
- Animal
- Human Disease Modelled
- Intervention
- Mercury, a toxic heavy metal, has been linked to many diseases in humans. Mercury is widely distributed in the environment, people would be exposed to them through food, drinking water and the surrounding air. Exposure is defined by the concentration of these elements in biological materials such as blood and urine.
- Comparator Control
- Since this review is not a clinical review, there may be a lack of alternatives to the subject matter of the review. It is possible to detect mercury in each person's biological sample, so the unexposed control group will be determined by the dose of these elements. Participants with the lowest mercury concentrations will be included in the control group.
- Main Outcome
- Relative risks, hazard ratios or odds ratios with corresponding 95% confidence intervals.
- Outcome Measure
- Additional Outcome
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Diabetes Mellitus, Type 2; Humans; Mercury; Metals, Heavy
- Contact
- Yun-Ran Guo [email protected]
- Organisational Affiliation
- The First Hospital of Jilin University
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-04-01
- Registration Date
- 2022-05-02
- Anticipated Start Date
- 2022-03-09
- Anticipated Completion Date
- 2022-04-30
- Title Cn
- 重金属汞与糖尿病的关联：一项系统评价与Meta分析
- Title En
- Association between heavy metal mercury and diabetes mellitus: A systematic review and meta-analysis
- Bilingual Status
- complete