Meta AnalysisID 2793
孕产妇汞暴露与妊娠期高血压综合征：一项系统评价与Meta分析
CRD42022297367
Is maternal mercury exposure associates with pregnancy-induced hypertension?
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2793
- Evidence Id
- 11351
- Core Evidence Id
- 11351
- Source Meta Analysis Id
- 2738
- Herb2 Meta Analysis Id
- HBMA002738
- Crd Id
- CRD42022297367
- Title
- Maternal mercury exposure and Gestational Hypertensive Syndromes: a systematic review and meta-analysis
- Review Question
- Is maternal mercury exposure associates with pregnancy-induced hypertension?
- Study Type Included
- Any observational analytical studies that compared normotensive and hypertensive pregnant or puerperal women. Review, animal and in vitro studies were excluded.
- Condition Being Studied
- Mercury is one of the ten most toxic substances in the world. World Health Organization considers it a significant public health concern due to its widespread distribution and persistence in the environment and its uptake and accumulation in the food chain. In addition, it has been associated with hypertension in humans and animal models. Pregnancy-Induced Hypertension (PIH) is a major cause of maternal, fetal, and newborn morbidity and mortality. Several lines of evidence suggest that mercury exposure may be associated with PIH.
- Participant
- The inclusion criteria comprised pregnant or puerperal women with PIH diagnosis and documented mercury exposure in any biological matrix. As measured outcomes, we included systolic and/or diastolic blood pressure, and/or hypertension.
- Animal
- Human Disease Modelled
- Intervention
- In order to assess mercury exposure, we included studies that measure mercury in blood, urine, cord blood, hair, and/or any other biological matrix.
- Comparator Control
- The control group comprised normotensive pregnant or puerperal woman and documented mercury exposure in any biological matrix.
- Main Outcome
- Pregnancy-Induced Hypertension is the main outcome. It comprises chronic hypertension (befora 20 weeks' gestation), gestational hypertension (after 20 weeks' gestation), pre-eclampsia (after 20 weeks's gestation with proteinuria or significant end-organ dysfunction with or withou proteinuria in the last half of pregnancy or postpartum), eclampsia (new onset of grand mal seizure activity and/or unexplained coma during pregnancy or postpartum in a woman with signs or symptoms of pre-eclampsia) Measures of effect Comparisons of means, relative risk, odds ratio, hazard ratio, and their standard or 95% confidence interval will be retrieved from the published data.
- Outcome Measure
- Additional Outcome
- Not applicable Measures of effect Not applicable
- Study Method
- Systematic review
- Keyword
- Female; Humans; Hypertension, Pregnancy-Induced; Mercury; Pregnancy; Syndrome
- Contact
- angelica dos santos vianna [email protected]
- Organisational Affiliation
- Universidade Federal do Rio de Janeiro
- Funding Source
- No funding sources/sponsors Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> Not applicable
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-12-09
- Registration Date
- 2022-01-09
- Anticipated Start Date
- 2021-11-01
- Anticipated Completion Date
- 2022-03-01
- Title Cn
- 孕产妇汞暴露与妊娠期高血压综合征：一项系统评价与Meta分析
- Title En
- Maternal mercury exposure and Gestational Hypertensive Syndromes: a systematic review and meta-analysis
- Bilingual Status
- complete