Meta AnalysisID 2791
人体汞暴露及其血液学影响：一项系统评价
CRD42018086389
Does human exposure to mercury lead to hematological effects?
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Record Fields
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- Meta Analysis Id
- 2791
- Evidence Id
- 11349
- Core Evidence Id
- 11349
- Source Meta Analysis Id
- 2737
- Herb2 Meta Analysis Id
- HBMA002737
- Crd Id
- CRD42018086389
- Title
- Human exposure to mercury and its hematological effects: a systematic review
- Review Question
- Does human exposure to mercury lead to hematological effects?
- Study Type Included
- It will be accept all types of studies such as clinical trials (randomized and non randomized), cohort, retrospective cohort, case control, cross-sectional, case series and case report. It will not be accept: book, review and author's opinion.
- Condition Being Studied
- Mercury is a well known toxic substance that can potentially impair function of any organ, such as bone marrow. The chosen definition for hematological effect was any blood cell alteration. So any change on bone marrow cellular series, such as anemia, polycythemia, leukocytosis, leukopenia, thrombocytosis, thrombocytopenia and so on, will be studied. There is sparse information about this particular subject.
- Participant
- Accepted will be people of any age, gender and ethnicity.
- Animal
- Human Disease Modelled
- Intervention
- It is important that the participants are or were exposed to mercury (information obtained by anamnesis and/or collected biomarker).
- Comparator Control
- Whenever there is a group of not exposed to mercury, it will be important to note if there is any difference on the outcome (number, type of hematological effect) (relative risk, odds ratio, prevalence ratio) between groups.
- Main Outcome
- Hematological effect is the primary outcome. It can be defined as any alteration of blood tissue analysis, which is divided in two parts: solid (cells) and liquid (plasma). For this study, it was established as any blood cell alteration. The used methods are CBC or blood cell count which measures the concentration of white blood cells, red blood cells, and platelets in the blood and aids in the diagnosis of conditions and diseases such as anemia. or bone marrow biopsy. Measures of effect If it is a result of a acute large dose exposure, it will be possible to measure the change on blood cells count in hours to a few days. If it is a result of a long low dose exposure it will be possible to measure it in years.
- Outcome Measure
- Additional Outcome
- Mercury may have direct toxic effect at other organ, for example skin (DRESS syndrome or Allergic Dermatitis) and this may lead to hematological effect such as eosinophilia. So hematological effect may be a be a direct or an indirect consequence of mercury toxicity. Measures of effect It has the same pattern as the primary outcome. If it is a result of a acute large dose exposure, it will be possible to measure the change on blood cells count in hours to a few days. If it is a result of a long low dose exposure it will be possible to measure it in months to years.
- Study Method
- Systematic review
- Keyword
- Environmental Exposure; Humans; Mercury; Occupational Exposure
- Contact
- Angelica Dos Santos Vianna [email protected]
- Organisational Affiliation
- Universidade Federal do Rio de Janeiro [email protected]
- Funding Source
- Professor Volney de Magalhães Câmara
- Other Selection Criteria
- Final Publication
- Vianna ADS, Matos EP, Jesus IM, Asmus CIRF, Câmara VM. Human exposure to mercury and its hematological effects: a systematic review. Cad Saude Publica. 2019 Feb 11;35(2):e00091618. doi: 10.1590/0102-311X00091618. http://cadernos.ensp.fiocruz.br/csp/public_site/arquivo/CSP_0916_18_SAGAS.pdf
- Same Topic Review
- Published Protocol
- Review Type
- Language
- Country
- Brazil
- Review Stage
- Review Completed published
- First Submission Date
- 2018-01-17
- Registration Date
- 2018-01-25
- Anticipated Start Date
- 2018-02-01
- Anticipated Completion Date
- 2018-05-01
- Title Cn
- 人体汞暴露及其血液学影响：一项系统评价
- Title En
- Human exposure to mercury and its hematological effects: a systematic review
- Bilingual Status
- complete