Meta AnalysisID 2789
儿童汞与孤独症的关系：一项Meta分析
CRD42016043439
Is there a relationship between mercury and autism in children?
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Record Fields
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- Meta Analysis Id
- 2789
- Evidence Id
- 11347
- Core Evidence Id
- 11347
- Source Meta Analysis Id
- 2735
- Herb2 Meta Analysis Id
- HBMA002735
- Crd Id
- CRD42016043439
- Title
- The relationship between mercury and autism in children: a meta-analysis
- Review Question
- Is there a relationship between mercury and autism in children?
- Study Type Included
- Case-control studies and, if possible, cohort studies.
- Condition Being Studied
- Autism spectrum disorders (ASD) is defined by deficits in social communication and social interaction, and restricted, repetitive patterns of behavior, interests, or activities. It is considered that the total fraction of ASD attributable to genetic inheritance may only be 30-40% and it has complex inheritance factors and genetic heterogeneity. However, a consensus is growing that non-genetic factors have a significant role in the etiology of ASD. In addition, many brain pathology studies indicate significant and ongoing neuroinflammation with concomitant neuronal damage in the disease. Various xenobiotics have been suggested as causal agents in the pathology of ASD. Five industrial chemicals are identified as developmental neurotoxicants based on epidemiological evidence: lead, methyl-mercury, polychlorinated biphenyls, arsenic, and toluene.
- Participant
- Patients (<19 years) suffering from ASD as cases, and healthy subjects (<19 years) as the control group.
- Animal
- Human Disease Modelled
- Intervention
- Level of mercury in the blood, hair, nails, and other possible tissues was compared between the case and the control group.
- Comparator Control
- The control group are healthy subjects (without ASD). The level of mercury in the blood, hair, nails, and other possible tissues was compared between the control group and patients with ASD.
- Main Outcome
- Autism spectrum disorders.
- Outcome Measure
- Additional Outcome
- Other neural diseases, if possible.
- Study Method
- Epidemiologic, Meta-analysis, Systematic review
- Keyword
- Autistic Disorder; Child; Environmental Exposure; Humans; Mercury; Risk Factors
- Contact
- Tina Jafari [email protected]
- Organisational Affiliation
- Department of Biochemistry and Nutrition, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Iran
- Review Stage
- Review Ongoing
- First Submission Date
- Registration Date
- 2016-07-30
- Anticipated Start Date
- 2016-07-23
- Anticipated Completion Date
- 2016-12-16
- Title Cn
- 儿童汞与孤独症的关系：一项Meta分析
- Title En
- The relationship between mercury and autism in children: a meta-analysis
- Bilingual Status
- complete