Meta AnalysisID 2743
重新评估质子泵抑制剂和组胺-2受体拮抗剂在危重患儿中的应用：系统评价和Meta分析
CRD42019130934
The aim of this review is to evaluate the evidence available regarding the administration of stress ulcer prophylaxis using histamine-2 antagonists and/or proton pump inhibitor in pediatric patients aged 7 days to 18 yea
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2743
- Evidence Id
- 11301
- Core Evidence Id
- 11301
- Source Meta Analysis Id
- 2693
- Herb2 Meta Analysis Id
- HBMA002693
- Crd Id
- CRD42019130934
- Title
- Reassessing the use of proton pump inhibitors and histamine-2 antagonists in critically ill children: a systematic review and meta-analysis
- Review Question
- The aim of this review is to evaluate the evidence available regarding the administration of stress ulcer prophylaxis using histamine-2 antagonists and/or proton pump inhibitor in pediatric patients aged 7 days to 18 years old, admitted to the ICU for more than 48 hours. The review seeks to investigate the effect of prophylaxis in preventing gastrointestinal hemorrhage; the complications of nosocomial pneumonia (including ventilator-associated pneumonia); the length of ICU stay and all-cause mortality to understand the risks and benefits of such intervention, so as to guide future management of critically ill children.
- Study Type Included
- We will include randomised controlled trials (RCTs) and observational studies (prospective or retrospective cohort studies) for this review.
- Condition Being Studied
- Prevention of stress ulcers in pediatric intensive care unit patients. Outcomes include gastrointestinal hemorrhage, nosocomial pneumonia, length of ICU stay and overall all-cause mortality.
- Participant
- Paediatric population aged 7 days old to 18 years old admitted into the intensive care unit for more than 48 hours. To exclude preterm infants.
- Animal
- Human Disease Modelled
- Intervention
- Stress ulcer prophylaxis using histamine-2 receptor antagonists (H2RAs) and/or proton pump inhibitors (PPIs) of any dose, frequency, duration or route of delivery. To exclude articles using these agents as treatment.
- Comparator Control
- Patients that did not receive stress ulcer prophylaxis in any form or received placebo treatment
- Main Outcome
- Gastrointestinal hemorrhage is defined as the presence of gross blood in gastric aspirates, as well as documented haematemesis, hematochezia or melena. Nosocomial pneumonia or hospital-acquired pneumonia, is defined as the development of lung parenchymal infection after at least 48 hours of hospitalization.
- Outcome Measure
- Additional Outcome
- Length of ICU stay and all-cause mortality
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Child; Critical Illness; Histamine; Histamine Antagonists; Histamine H2 Antagonists; Humans; Proton Pump Inhibitors
- Contact
- Dominic Yao [email protected]
- Organisational Affiliation
- Duke-NUS Medical School
- Funding Source
- Singhealth Duke-NUS Academic Clinical Programme
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Singapore
- Review Stage
- Review Ongoing
- First Submission Date
- 2019-04-04
- Registration Date
- 2019-05-09
- Anticipated Start Date
- 2018-10-30
- Anticipated Completion Date
- 2019-05-10
- Title Cn
- 重新评估质子泵抑制剂和组胺-2受体拮抗剂在危重患儿中的应用：系统评价和Meta分析
- Title En
- Reassessing the use of proton pump inhibitors and histamine-2 antagonists in critically ill children: a systematic review and meta-analysis
- Bilingual Status
- complete